Phenotypes Associated with This Genotype

Genotype
MGI:5829751

• Allelic Composition: Ank3^tm3Bnt/Ank3^tm3Bnt; Tg(Nes-cre)1Kln/?
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:218905 )

• mice live up to 20 days

nervous system

abnormal hippocampus neuron morphology ( J:218905 )

• loss of polarity of the proximal axon from hippocampus is observed in 16-20 day old mice

• hippocampal neurons exhibit a complete loss of submembranous fibrillogranular coat

• tight bundling of microtubules is lost

abnormal axon morphology ( J:218905 )

• proximal axon of Purkinje neuron is increased in diameter

• loss of polarity of the proximal axon from hippocampus is observed in 16-20 day old mice

• proximal axons from hippocampal neurons develop dendritic properties such as dendritic spines, however, in culture axon characteristics resume 50-100 um from the soma and distal axon polarity is maintained

abnormal Purkinje cell axon morphology ( J:218905 )

• proximal axon of Purkinje neuron is increased in diameter

abnormal axon initial segment morphology ( J:218905 )

abnormal node of Ranvier morphology ( J:218905 )

• 80% decrease in number of nodes of Ranvier in corpus callosum

• remaining nodes are malformed with greatly increased lengths

abnormal paranodal axoglial junction morphology ( J:218905 )

• increase in isolated (unpaired) paranodal axo-glial junctions

abnormal nervous system electrophysiology ( J:218905 )

abnormal action potential ( J:218905 )

• peak frequency of action potential firing is decreased in cortex and striatum

• single action potentials exhibit an increase in tau for both rise and decay

abnormal brain wave pattern ( J:218905 )

• decrease in cortical gamma oscillations as compared to controls

abnormal brain alpha wave pattern ( J:218905 )

• increase in alpha oscillations in motor cortex as compared to controls