Phenotypes Associated with This Genotype

Genotype
MGI:5613965

• Allelic Composition: Angpt1^tm1.1Seq/Angpt1^tm1.1Seq; Angpt2^{tm1c(KOMP)Seq}/Angpt2^{tm1c(KOMP)Seq}; Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/?; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129 * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cornea vascularization ( J:217296 )

• capillary loops extend into the cornea

vision/eye

abnormal eye morphology ( J:217296 )

• in mice exposed to deoxycycline treatment at E16.5

abnormal anterior eye segment morphology ( J:217296 )

absent Schlemm's canal ( J:217296 )

abnormal cornea morphology ( J:217296 )

• lymphatic vasculature develops in the corneal limbus

cornea vascularization ( J:217296 )

• capillary loops extend into the cornea

increased cornea size ( J:217296 )

• enlarged

increased eye anterior chamber depth ( J:217296 )

• increased anterior chamber depth

buphthalmos ( J:217296 )

• eyes begin to protrude by 21 to 28 days of age

• difficulty closing eyelids by 8 weeks of age

abnormal retina layer morphology ( J:217296 )

• reduced thickness of retinal cell layer

thin retina ganglion layer ( J:217296 )

thin retina inner nuclear layer ( J:217296 )

abnormal retina nerve fiber layer morphology ( J:217296 )

• reduced thickness

thin retina outer nuclear layer ( J:217296 )

• becoming worse toward periphery

abnormal eye physiology ( J:217296 )

• in mice exposed to deoxycycline treatment at E16.5

abnormal intraocular pressure ( J:217296 )

• elevated

decreased visual acuity ( J:217296 )

• severely impaired vision

immune system

abnormal lymphatic vessel morphology ( J:217296 )

• lymphatic vessels are sparse in the dermis of the ear

• abnormal branching of lymphatic vessels