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Phenotypes Associated with This Genotype
Genotype
MGI:5587948
Allelic
Composition
Bsgtm1.1Znc/Bsgtm1.1Znc
Tg(Lck-cre)19Hhan/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bsgtm1.1Znc mutation (0 available); any Bsg mutation (17 available)
Tg(Lck-cre)19Hhan mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• at 2 and 5 weeks, mice exhibit normal absolute numbers of double negative and CD8 single positive thymocytes and double positive thymocyte apoptosis rates
• at 2 and 5 weeks
• double positive thymocytes at 2 and 5 weeks
• CD4 single positive thymocytes at 2 and 5 weeks
• increased activation in CD4+ T cells stimulated with ConA and anti-CD3/CD28 antibodies
• in CD4+ T cells stimulated with ConA and anti-CD3/CD28 antibodies
• however, PMA/ionomycin-stimulated CD4+ T cells exhibit normal proliferation

endocrine/exocrine glands
• at 2 and 5 weeks

hematopoietic system
• at 2 and 5 weeks
• double positive thymocytes at 2 and 5 weeks
• CD4 single positive thymocytes at 2 and 5 weeks
• increased activation in CD4+ T cells stimulated with ConA and anti-CD3/CD28 antibodies
• in CD4+ T cells stimulated with ConA and anti-CD3/CD28 antibodies
• however, PMA/ionomycin-stimulated CD4+ T cells exhibit normal proliferation

cellular
• in CD4+ T cells stimulated with ConA and anti-CD3/CD28 antibodies
• however, PMA/ionomycin-stimulated CD4+ T cells exhibit normal proliferation


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory