Phenotypes Associated with This Genotype

Genotype
MGI:5526066

• Allelic Composition: Mrap2^tm1.1Maj/Mrap2^tm1.1Maj
• Genetic Background: either: B6.129-Mrap2^tm1.1Maj or (involves: 129 * 129S6/SvEvTac)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:199365 )

N • locomotor activity is similar to littermate controls at 30-45 days of age

increased food intake ( J:199365 )

• normal weight gain and post-weaning food intake during early life (0 to 32 days and 23 to 32 days, respectively), increase food intake with advancing age, starting after 32 days of age

increased compensatory feeding amount ( J:199365 )

• food intake almost doubles after 40 days of restricted feeding

polyphagia ( J:199365 )

• no difference when analyzed over a 4-day interval

• subtle increase in food intake is noticeable when monitored over 50 days (ages 34 to 84 days), with the onset of obesity preceding hyperphagia

• age-dependent in older mice and independent of body weight

growth/size/body

decreased lean body mass ( J:199365 )

• as a percent of total body mass

obese ( J:199365 )

• gradually become extremely obese starting after 32 days of age, with onset of obesity preceding hyperphagia

increased body length ( J:199365 )

increased susceptibility to weight gain ( J:199365 )

• mice gain more weight even when food intake is restricted to match littermate controls

• increase weight gain in mutant mice unless food intake is restricted to 10% (females) and 13% (males) less than that of littermate controls

adipose tissue

increased brown adipose tissue amount ( J:199365 )

• enlarged brown adipose tissue depots

increased total body fat amount ( J:199365 )

• increase in visceral adiposity

increased white fat cell size ( J:199365 )

• greater than twice the size of cells in controls

increased percent body fat/body weight ( J:199365 )

liver/biliary system

hepatic steatosis ( J:199365 )

• normal while on a regular chow diet but much greater hepatic steatosis on a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:199365 )

N • fasting insulin, glucose tolerance, corticosterone levels, thyroid hormone levels, energy expenditure, respiratory quotient, and body temperature are similar to controls in adult obese mice

increased circulating leptin level ( J:199365 )

• in adult obese mice

abnormal adrenaline level ( J:199365 )

♂ • significantly reduced

abnormal noradrenaline level ( J:199365 )

♂ • significantly reduced

digestive/alimentary system

abnormal intestinal absorption ( J:199365 )

• no difference in calories absorption