Phenotypes Associated with This Genotype

Genotype
MGI:5475213

• Allelic Composition: Pkn1^tm1Kik/Pkn1^tm1Kik
• Genetic Background: B6.129P2-Pkn1^tm1Kik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Development of glomerulonephritis in Pkn1^tm1Kik/Pkn1^tm1Kik mice

immune system

immune system phenotype ( J:193187 )

N • stimulated T cell proliferation is normal

decreased activation-induced B cell apoptosis ( J:193187 )

increased B cell proliferation ( J:193187 )

• of B cells stimulated with anti-IgM antibody alone or with anti-CD40 antibody and treated with BAFF or IL4

• however, proliferation in response to stimulation with anti-CD40 antibody, BAFF or IL4 alone is normal

abnormal somatic hypermutation frequency ( J:193187 )

• reduced at the Ig locus in germinal center B cells

increased germinal center B cell number ( J:193187 )

• spontaneous in mice after 30 weeks

• 7-fold after immunization

increased spleen germinal center size ( J:193187 )

• after immunization

increased splenocyte number ( J:193187 )

• in mice after 30 weeks

abnormal germinal center B cell physiology ( J:193187 )

• spontaneous formation in the absence of immunization or infection in mice after 30 weeks

• abnormal germinal center formation is cell intrinsic

increased IgG1 level ( J:193187 )

• spontaneous in mice after 30 weeks

• however, levels are normal after immunization

increased IgG2a level ( J:193187 )

• spontaneous in mice after 30 weeks

increased IgG2b level ( J:193187 )

• spontaneous in mice after 30 weeks

increased IgM level ( J:193187 )

• spontaneous in mice after 30 weeks

• however, levels are normal after immunization

increased anti-double stranded DNA antibody level ( J:193187 )

• in mice after 30 weeks

glomerulonephritis ( J:193187 )

• with IgG and complement C3 deposition in the mesangial region in mice after 30 weeks

renal/urinary system

increased mesangial cell number ( J:193187 )

• in mice after 30 weeks

glomerulonephritis ( J:193187 )

• with IgG and complement C3 deposition in the mesangial region in mice after 30 weeks

increased renal glomerulus basement membrane thickness ( J:193187 )

• in mice after 30 weeks

renal glomerular immunoglobulin deposits ( J:193187 )

cellular

increased mesangial cell number ( J:193187 )

• in mice after 30 weeks

decreased activation-induced B cell apoptosis ( J:193187 )

increased B cell proliferation ( J:193187 )

• of B cells stimulated with anti-IgM antibody alone or with anti-CD40 antibody and treated with BAFF or IL4

• however, proliferation in response to stimulation with anti-CD40 antibody, BAFF or IL4 alone is normal

hematopoietic system

decreased activation-induced B cell apoptosis ( J:193187 )

increased B cell proliferation ( J:193187 )

• of B cells stimulated with anti-IgM antibody alone or with anti-CD40 antibody and treated with BAFF or IL4

• however, proliferation in response to stimulation with anti-CD40 antibody, BAFF or IL4 alone is normal

abnormal somatic hypermutation frequency ( J:193187 )

• reduced at the Ig locus in germinal center B cells

increased germinal center B cell number ( J:193187 )

• spontaneous in mice after 30 weeks

• 7-fold after immunization

increased spleen germinal center size ( J:193187 )

• after immunization

increased splenocyte number ( J:193187 )

• in mice after 30 weeks

abnormal germinal center B cell physiology ( J:193187 )

• spontaneous formation in the absence of immunization or infection in mice after 30 weeks

• abnormal germinal center formation is cell intrinsic

increased IgG1 level ( J:193187 )

• spontaneous in mice after 30 weeks

• however, levels are normal after immunization

increased IgG2a level ( J:193187 )

• spontaneous in mice after 30 weeks

increased IgG2b level ( J:193187 )

• spontaneous in mice after 30 weeks

increased IgM level ( J:193187 )

• spontaneous in mice after 30 weeks

• however, levels are normal after immunization