Analysis Tools
mortality/aging
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• Background Sensitivity: unlike mice on a mixed background with 129 that die at E13, mice on a variety of congenic backgrounds or a mixed background with CD-1 die shortly after birth due to cleft palate
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craniofacial
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• at E15.5, epithelium and mesenchyme cell proliferation in molars is increased compared to in wild-type mice
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• molars exhibit temporal tooth development arrest at a bud stage with a gradual decrease in epithelium and mesenchyme cell proliferation between E13.5 and E14.5 compared to in wild-type mice
• however, molar development is normal by E16.5
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cleft palate
(
J:180393
)
digestive/alimentary system
cleft palate
(
J:180393
)
cellular
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• in the epithelium and mesenchyme cells of molars between E13.5 and E14.5
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• in the epithelium and mesenchyme cells of molars between E15.5
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growth/size/body
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• at E15.5, epithelium and mesenchyme cell proliferation in molars is increased compared to in wild-type mice
|
|
• molars exhibit temporal tooth development arrest at a bud stage with a gradual decrease in epithelium and mesenchyme cell proliferation between E13.5 and E14.5 compared to in wild-type mice
• however, molar development is normal by E16.5
|
cleft palate
(
J:180393
)
skeleton
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• at E15.5, epithelium and mesenchyme cell proliferation in molars is increased compared to in wild-type mice
|
|
• molars exhibit temporal tooth development arrest at a bud stage with a gradual decrease in epithelium and mesenchyme cell proliferation between E13.5 and E14.5 compared to in wild-type mice
• however, molar development is normal by E16.5
|
