Phenotypes Associated with This Genotype

Genotype
MGI:5304813

• Allelic Composition: Il17c^tm1Lex/Il17c^tm1Lex
• Genetic Background: B6.129S5-Il17c^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

decreased keratinocyte proliferation ( J:178967 )

• in imiquimod-treated mice

abnormal epidermal layer morphology ( J:178967 )

• imiquimod-treated mice exhibit reduced inflammation and epidermal thickening compared with wild-type mice

psoriasis ( J:178967 )

• imiquimod-treated mice exhibit reduced inflammation, proinflammatory cytokines, epidermal pustules of pinnea, epidermal thickening, and keratinocyte proliferation compared with wild-type mice

immune system

immune system phenotype ( J:178967 )

N • mice exhibit normal DSS-treated colitis

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:178967 )

• imiquimod-treated mice exhibit reduced inflammation, proinflammatory cytokines, epidermal pustules of pinnea, epidermal thickening, and keratinocyte proliferation compared with wild-type mice

digestive/alimentary system

digestive/alimentary phenotype ( J:178967 )

N • mice exhibit normal DSS-treated colitis

cellular

decreased keratinocyte proliferation ( J:178967 )

• in imiquimod-treated mice