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Phenotypes Associated with This Genotype
Genotype
MGI:4831154
Allelic
Composition		 Actbtm1(INSR)Dac/Actbtm1(INSR)Dac
Insrtm1Dac/Insrtm1Dac
Tg(Nes-cre)1Kln/?
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actbtm1(INSR)Dac mutation (0 available); any Actb mutation (52 available)
Insrtm1Dac mutation (2 available); any Insr mutation (95 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:91350 )
• die between 6 and 8 weeks

homeostasis/metabolism
increased circulating glucose level ( J:91350 )
• diabetic in one week
increased circulating insulin level ( J:91350 )
• extremely elevated

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory