Phenotypes Associated with This Genotype

Genotype
MGI:4462157

• Allelic Composition: Zdhhc21^dep/Zdhhc21^dep
• Genetic Background: involves: C57BL/6J * STOCK T tf/+ tf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

enlarged sebaceous gland ( J:161749 )

• enlarged sebaceous glands with an excess of sebum

sebaceous gland hyperplasia ( J:161749 )

• mild sebaceous gland hyperplasia at P5

abnormal sebaceous gland physiology ( J:161749 )

• increase in the percentage of BrdU positive, proliferating cells that are observed in sebaceous glands

increased sebum secretion ( J:161749 )

• excess of sebum

integument

enlarged sebaceous gland ( J:161749 )

• enlarged sebaceous glands with an excess of sebum

sebaceous gland hyperplasia ( J:161749 )

• mild sebaceous gland hyperplasia at P5

abnormal sebaceous gland physiology ( J:161749 )

• increase in the percentage of BrdU positive, proliferating cells that are observed in sebaceous glands

increased sebum secretion ( J:161749 )

• excess of sebum

abnormal coat appearance ( J:161749 )

greasy coat ( J:161749 )

underdeveloped hair follicles ( J:161749 )

• second hair cycle around P28, the follicles are growth retarded and immature compared to wild-type

dilated hair follicle infundibulum ( J:161749 )

• in telogen defects in the permanent portions of the skin are apparent, include a dilated infundibulum

abnormal hair follicle physiology ( J:161749 )

• decrease of proliferating cells in hair follicles during anagen

abnormal epidermal layer morphology ( J:161749 )

• slight thickening of the interfollicular epidermis develop at P5

epidermal cyst ( J:161749 )

• small epidermal cysts containing keratinized material are observed in the upper portion of the dermis

thick epidermis ( J:161749 )

abnormal skin physiology ( J:161749 )

• increase in the fraction of BrdU positive, proliferating interfollicular epidermis cells

• delayed differentiation of the expanded basal progenitor compartment

craniofacial

craniofacial phenotype ( J:177282 )

N • mutants do not exhibit sutural abnormalities

growth/size/body

epidermal cyst ( J:161749 )

• small epidermal cysts containing keratinized material are observed in the upper portion of the dermis