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Phenotypes Associated with This Genotype
Genotype
MGI:3851452
Allelic
Composition
Pde1ctm1.1Hazh/Pde1ctm1.1Hazh
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde1ctm1.1Hazh mutation (0 available); any Pde1c mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
• olfacotory sensory nerves (OSN) that fire in response to amyl acetate and heptaldehyde have faster response termination of their action potentials compared to controls
• OSN also have significantly reduced amplitudes with slower onset kinetics
• amplitude is about half that of controls
• mice have attenuated odor adaptation on second encounter to ameyl acetate compared to controls
• this attenuation is observed when there is a 1 or 2 second pause between the two encounters but not with longer time intervals
• mice have normal odor adaptation to sustained odor stimulus


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory