Analysis Tools
digestive/alimentary system
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• the number of zymogen cells in the stomach is reduced compared to in wild-type mice
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• some parietal cells appear flattened and their numbers are 40% of wild-type
• parietal cells lack tubulovesicles found in wild-type cells
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• at 5 to 6 weeks of age, mice exhibit dilated gastric glands compared to in wild-type mice
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• mucus cells contain numerous hyaline granules unlike in wild-type mice
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• the stomach epithelium is thicker than in wild-type mice
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• total secretory membranes (apical microvilli, canaicular microvillia and tubulovesicles) are decreased compared to in wild-type stomachs
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• at 5 to 6 weeks of age, no gastric acid is secreted even when mice are stimulated with forskolin and KCl
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• 17 to 19 days, gastric acid secretion is reduced 49% compared to in wild-type mice
• however, mice 7 to 9 days old exhibit normal basal and forskolin-stimulated gastric acid secretion
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• stomach pH is more alkaline than in wild-type mice
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endocrine/exocrine glands
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• the number of zymogen cells in the stomach is reduced compared to in wild-type mice
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• some parietal cells appear flattened and their numbers are 40% of wild-type
• parietal cells lack tubulovesicles found in wild-type cells
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• at 5 to 6 weeks of age, mice exhibit dilated gastric glands compared to in wild-type mice
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