Phenotypes Associated with This Genotype

Genotype
MGI:3821761

cn3

• Allelic Composition: Igf1^tm2Arge/Igf1^tm2Arge; Tg(SERPINA1-cre)1Arge/0
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:142247 )

• only 11% of neonates survive

neonatal lethality, incomplete penetrance ( J:142247 )

• only 11% of neonates survive

reproductive system

reproductive system phenotype ( J:142247 )

N • unlike Igf1^tm2Arge homozygotes, mice are fertile

growth/size/body

decreased body weight ( J:142247 )

• mice weigh 50% of wild-type

homeostasis/metabolism

decreased circulating insulin-like growth factor I level ( J:142247 )

• at E18.5, IGF1 serum levels are below detectable levels

• at P72, IGF1 serum levels are 44% of normal