Phenotypes Associated with This Genotype

Genotype
MGI:3803200

• Allelic Composition: Aire^tm1.1Doi/Aire^tm1.1Doi
• Genetic Background: NOD.129S2-Aire^tm1.1Doi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:135154 )

• mice 10 weeks of age have severe lymphocytic infiltration of the salivary glands

stomach inflammation ( J:135154 )

• occurs in mice by 10 weeks of age

thyroid gland inflammation ( J:135154 )

• severe thyroiditis is observed in mice 15 to 25 weeks in age

lacrimal gland inflammation ( J:135154 )

• mice 10 weeks of age have severe lymphocytic infiltration of the lacrimal glands

chronic pancreas inflammation ( J:135154 )

• mice 10 weeks have age have severe lymphocytic infiltration of the pancreas

insulitis ( J:135154 )

• mice 25 weeks of age have intra-islet infiltration of lymphocytes

abnormal CD4-positive, alpha-beta T cell physiology ( J:135154 )

• there is increased percentage of CD4 T cells in the spleen that are activated based on surface marker expression (CD62L^lo CD44^hi)

uveitis ( J:135154 )

• retinal lymphocytic infiltration occurs in the eye

lung inflammation ( J:135154 )

• lymphocyte infiltrates are found in mice by 10 weeks of age

endocrine/exocrine glands

salivary gland inflammation ( J:135154 )

• mice 10 weeks of age have severe lymphocytic infiltration of the salivary glands

thyroid gland inflammation ( J:135154 )

• severe thyroiditis is observed in mice 15 to 25 weeks in age

lacrimal gland inflammation ( J:135154 )

• mice 10 weeks of age have severe lymphocytic infiltration of the lacrimal glands

chronic pancreas inflammation ( J:135154 )

• mice 10 weeks have age have severe lymphocytic infiltration of the pancreas

insulitis ( J:135154 )

• mice 25 weeks of age have intra-islet infiltration of lymphocytes

respiratory system

lung inflammation ( J:135154 )

• lymphocyte infiltrates are found in mice by 10 weeks of age

vision/eye

lacrimal gland inflammation ( J:135154 )

• mice 10 weeks of age have severe lymphocytic infiltration of the lacrimal glands

uveitis ( J:135154 )

• retinal lymphocytic infiltration occurs in the eye

digestive/alimentary system

salivary gland inflammation ( J:135154 )

• mice 10 weeks of age have severe lymphocytic infiltration of the salivary glands

stomach inflammation ( J:135154 )

• occurs in mice by 10 weeks of age

hematopoietic system

abnormal CD4-positive, alpha-beta T cell physiology ( J:135154 )

• there is increased percentage of CD4 T cells in the spleen that are activated based on surface marker expression (CD62L^lo CD44^hi)