Phenotypes Associated with This Genotype

Genotype
MGI:3794739

• Allelic Composition: Sftpa1^tm1Kor/Sftpa1^tm1Kor
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

lung inflammation ( J:107841 )

• LPS-induced injury increases the number of alveolar resident cells compared to in similarly treated wild-type mice

abnormal surfactant physiology ( J:107841 )

• LPS-induced injury decreases surfactant clearance 40% compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal phospholipid level ( J:107841 )

• LPS-induced injury increases the level of phospholipids in lavage fluid 1.6-fold compared to in similarly treated wild-type mice

immune system

immune system phenotype ( J:130958 )

N • mice exhibit a normal inflammatory response following infection with Cryptococcus neoformans

lung inflammation ( J:107841 )

• LPS-induced injury increases the number of alveolar resident cells compared to in similarly treated wild-type mice