Phenotypes Associated with This Genotype

Genotype
MGI:3716692

• Allelic Composition: Bsx^tm1Tre/Bsx^tm1Tre
• Genetic Background: B6.129-Bsx^tm1Tre

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal food intake ( J:122746 )

• fasted mice ingest 40% less than fasted wild-type mice

• when treated with ghrelin, mutants do not increase food intake in contrast to wild-type animals

decreased locomotor activity ( J:122746 )

• locomotor activity is severely reduced at 12 weeks of age

• upon fasting, activity level does not increase as it does in fasted wild-type mice

adipose tissue

increased percent body fat/body weight ( J:122746 )

• a significant increase in fat mass is observed compared to wild-type, but no significant increase in body weight

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:122746 )

N • serum glucose and insulin levels are similar to those measured in wild-type controls

abnormal circadian temperature homeostasis ( J:122746 )

• mice have significantly lower core temperatures during the 12 hour period of darkness (~37 degrees C vs ~ 40 degrees C in wild-type)

decreased respiratory quotient ( J:122746 )

• slightly decreased relative to wild-type