Phenotypes Associated with This Genotype

Genotype
MGI:3689074

• Allelic Composition: Cd74^tm1Liz/Cd74^tm1Liz
• Genetic Background: involves: 129S/SvEv * BALB/c * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact hen egg lysozyme (HEL) protein antigen are reduced in mutants, but immunized mice challenged secondarily with HEL_46-61 peptide show similar response to wild-type mice

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

abnormal dendritic cell antigen presentation ( J:110927 )

• dendritic cells show reduced class II surface expression in overnight culture compared to wild-type

abnormal antigen presentation via MHC class II ( J:110927 )

• spleen cells effectively function as stimulators for allogeneic T cells, eliciting strong mixed lymphocyte responses

hematopoietic system

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact hen egg lysozyme (HEL) protein antigen are reduced in mutants, but immunized mice challenged secondarily with HEL_46-61 peptide show similar response to wild-type mice

abnormal B cell differentiation ( J:110927 )

• B cell maturation is defective

increased immature B cell number ( J:110927 )

• higher percentages of immature B cells lacking surface IgD and CD23 expression

cellular

abnormal T cell proliferation ( J:110927 )

• proliferative responses to intact hen egg lysozyme (HEL) protein antigen are reduced in mutants, but immunized mice challenged secondarily with HEL_46-61 peptide show similar response to wild-type mice