Phenotypes Associated with This Genotype

Genotype
MGI:3626171

• Allelic Composition: Smarca4^enu1/Smarca4^tm1Mag
• Genetic Background: involves: 129S/Sv * C57BL/10 * CBA/Cbi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:103896 )

• mutants survive until midgestation but then die as a result of severe anemia; lethality begins at E11.5 and all mutants are dead by E14.5

hematopoietic system

abnormal blood cell morphology/development ( J:103896 )

• in Smarca1^enu1/Smarca^tm1Mag mutants, the developmental switch of erythropoiesis from the yolk sac to the fetal liver around E10.5 does not occur properly and yolk sac-derived erythrocytes persist for several days

• At E12.5, mutants still alive showed greatly diminished erythropoiesis in the fetal liver

abnormal erythrocyte morphology ( J:103896 )

• mutants have proerythroblasts and basophilic erythroblasts but lack mature polychromatic erythroblasts, orthochromatic erythroblasts and enucleated reticulocytes

liver/biliary system

abnormal liver morphology ( J:103896 )

• mutant fetal livers have a red speckled appearance or are completely pale