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Phenotypes Associated with This Genotype
Genotype
MGI:2673140
Allelic
Composition		 Mcpt4tm1Mabr/Mcpt4tm1Mabr
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcpt4tm1Mabr mutation (0 available); any Mcpt4 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:84839 )
• mast cell count and morphology were normal
• loss of chymotryptic activity in peritoneal mast cells and in ear tissue extracts

homeostasis/metabolism
abnormal blood coagulation ( J:84839 )
• slower inactivation of thrombin
• reduced processing of fibronectin

hematopoietic system
abnormal mast cell physiology ( J:84839 )
• mast cell count and morphology were normal
• loss of chymotryptic activity in peritoneal mast cells and in ear tissue extracts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory