Analysis Tools
immune system
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• about a 2-fold increase compared to wild-type
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• in young (6 weeks of age) but not old (5 - 6 months of age) mice B cells are larger and appear to mostly be activated
• however, cells that do mature display normal allelic exclusion
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• at 5-6 weeks of age in the peripheral blood; T cell numbers are similar to wild-type
(J:64284)
• at 5-6 weeks of age the ratio of B to T cells in the blood is decreased about 25- to 65-fold relative to wild-type mice and the number of splenic B cells is reduced about 10- to 30-fold
(J:64284)
• at 4 months of age, B cells numbers in the blood and spleen are reduced 5- to 13-fold and 3- to 5-fold, respectively
(J:64284)
• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice
(J:35357)
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• at 2 weeks of age the number of lymphocytes in the peritoneum is reduced; however, at 5-7 weeks of age the number of B-1 cells in the peritoneum is similar to or increased compared to wild-type mice
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• about a 2-fold increase in large early pre-B cells and a 40-fold decrease in small pre-B cells compared to wild-type
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• spleen cellularity is reduced about 4-fold and 2-fold at 2 weeks and 5-6 weeks of age, respectively
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• decreased levels of IgG3, IgG2b, and, to a lesser degree, IgG1 in response to a T-cell dependent antigen with overall antibody response reduced about 5- to 10-fold
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hematopoietic system
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• about a 2-fold increase compared to wild-type
|
|
• in young (6 weeks of age) but not old (5 - 6 months of age) mice B cells are larger and appear to mostly be activated
• however, cells that do mature display normal allelic exclusion
|
|
• at 5-6 weeks of age in the peripheral blood; T cell numbers are similar to wild-type
(J:64284)
• at 5-6 weeks of age the ratio of B to T cells in the blood is decreased about 25- to 65-fold relative to wild-type mice and the number of splenic B cells is reduced about 10- to 30-fold
(J:64284)
• at 4 months of age, B cells numbers in the blood and spleen are reduced 5- to 13-fold and 3- to 5-fold, respectively
(J:64284)
• in the spleen at 6 - 12 weeks of age, B cell numbers are about 1/3 that of wild-type mice
(J:35357)
|
|
• at 2 weeks of age the number of lymphocytes in the peritoneum is reduced; however, at 5-7 weeks of age the number of B-1 cells in the peritoneum is similar to or increased compared to wild-type mice
|
|
• about a 2-fold increase in large early pre-B cells and a 40-fold decrease in small pre-B cells compared to wild-type
|
|
• spleen cellularity is reduced about 4-fold and 2-fold at 2 weeks and 5-6 weeks of age, respectively
|
|
• decreased levels of IgG3, IgG2b, and, to a lesser degree, IgG1 in response to a T-cell dependent antigen with overall antibody response reduced about 5- to 10-fold
|
