Slc9b2^tm1.1Liuy
Targeted Allele Detail

Summary

• Symbol: Slc9b2^tm1.1Liuy
• Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; targeted mutation 1.1, Yi-Xun Liu
• MGI ID: MGI:8192189
• Synonyms: Nha2^Fx
• Gene: Slc9b2 Location: Chr3:135013083-135048606 bp, + strand Genetic Position: Chr3, 62.55 cM
• Alliance: Slc9b2^tm1.1Liuy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240371
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP-flanked PGK-neomycin cassette was inserted downstream of exon 3. The neomycin cassette was removed via cre-mediated recombination, leaving exon 3 floxed. (J:240371)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9b2 Mutation: 43 strains or lines available

References

• Original: J:240371 Chen SR, et al., Sodium-hydrogen exchanger NHA1 and NHA2 control sperm motility and male fertility. Cell Death Dis. 2016 Mar 24;7:e2152
• All: 1 reference(s)