Syk^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Syk^tm1.1Ics
• Name: spleen tyrosine kinase; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:7779937
• Synonyms: Syk^fl
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:349153
• Parent Cell Line: S3 (ES Cell)
• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted into intron 3. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. (J:349153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 41 strains or lines available

References

• Original: J:349153 Kassouf T, et al., The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex. Cancers (Basel). 2019 Dec 7;11(12)
• All: 1 reference(s)