Cd276^tm1.2Bcgen
Targeted Allele Detail

Summary

• Symbol: Cd276^tm1.2Bcgen
• Name: CD276 antigen; targeted mutation 1.2, Biocytogen LLC
• MGI ID: MGI:7310467
• Gene: Cd276 Location: Chr9:58431581-58462720 bp, - strand Genetic Position: Chr9, 31.79 cM
• Alliance: Cd276^tm1.2Bcgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326342
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were floxed and an FRT-flanked neo cassette was inserted via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 3 and 4. (J:326342)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd276 Mutation: 21 strains or lines available

References

• Original: J:326342 Cai D, et al., Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy. Cell Mol Immunol. 2020 Mar;17(3):227-236
• All: 2 reference(s)