Cd47^em1Hwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd47^em1Hwl
• Name: CD47 antigen (Rh-related antigen, integrin-associated signal transducer); endonuclease-mediated mutation 1, Han-Woong Lee
• MGI ID: MGI:6363068
• Gene: Cd47 Location: Chr16:49671691-49732799 bp, + strand Genetic Position: Chr16, 31.23 cM
• Alliance: Cd47^em1Hwl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion of 26 base pairs in exon 1, which created a frameshift mutation and a premature stop codon. (J:278850)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd47 Mutation: 45 strains or lines available

References

• Original: J:278850 Kim JI, et al., CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice. Lab Anim Res. 2018 Dec;34(4):302-310
• All: 1 reference(s)