Compare GO annotations for TSC2 and its OrthoDisease orthologs

Compare GO annotations for TSC2 and its orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: mouse, human, rat, worm, fly, dicty, chicken, zfin, rice, tair, yeast, pombe, pfalc, and multiple.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Mouse from MGI; Human from GO Annotations @ EBI (GOA); Rat from RGD; Chicken from GOA; Fly from FlyBase; Pfalc from PlasmoDB; Worm from WormBase; Dicty from dictyBase; Yeast from SGD; Zfin from ZFIN; Tair from TAIR/TIGR; Rice from Gramene; Pombe from Sanger GeneDB.
Does not include evidence codes: IEA, ISS, RCA, NR, ND, NAS, IC, IGC, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
All nodes are linked to the MGI GO browser.
Graph generated Fri Dec 7 09:49:59 2007.

Category	ID	Term	DB Object	Evidence	Organism	Reference
Molecular Function	GO:0005096	GTPase activator activity	RGD:3908	IDA	Rat	RGD:1580520\|PMID:12869586
Molecular Function	GO:0030695	GTPase regulator activity	RGD:3908	IMP	Rat	RGD:1601406\|PMID:15611338
Molecular Function	GO:0005515	protein binding	MGI:102548	IPI	Mouse	MGI:MGI:2155582\|PMID:11741832
Molecular Function	GO:0005515	protein binding	P49815	IPI	Human	PMID:12364343
Molecular Function	GO:0005515	protein binding	P49815	IPI	Human	PMID:9580671
Molecular Function	GO:0005515	protein binding	P49815	IPI	Human	PMID:10585443
Molecular Function	GO:0005515	protein binding	RGD:3908	IPI	Rat	RGD:1304444\|PMID:14559897
Molecular Function	GO:0005515	protein binding	RGD:3908	IPI	Rat	RGD:1601351\|PMID:17379185
Molecular Function	GO:0005515	protein binding	RGD:3908	IMP	Rat	RGD:1601406\|PMID:15611338
Molecular Function	GO:0046982	protein heterodimerization activity	RGD:3908	IPI	Rat	RGD:1580491\|PMID:15093748
Molecular Function	GO:0042803	protein homodimerization activity	P49815	IPI	Human	PMID:10585443
Cellular Component	GO:0016599	caveolar membrane	RGD:3908	IDA	Rat	RGD:1580491\|PMID:15093748
Cellular Component	GO:0005737	cytoplasm	MGI:102548	IDA	Mouse	MGI:MGI:2155582\|PMID:11741832
Cellular Component	GO:0005737	cytoplasm	P49815	IDA	Human	PMID:9580671
Cellular Component	GO:0044430	cytoskeletal part	RGD:3908	IDA	Rat	RGD:1601407\|PMID:12147258
Cellular Component	GO:0005829	cytosol	P49815	IDA	Human	PMID:10585443
Cellular Component	GO:0005829	cytosol	RGD:3908	IDA	Rat	RGD:1601407\|PMID:12147258
Cellular Component	GO:0030426	growth cone	RGD:3908	IDA	Rat	RGD:1304444\|PMID:14559897
Cellular Component	GO:0045121	lipid raft	RGD:3908	IDA	Rat	RGD:1580491\|PMID:15093748
Cellular Component	GO:0005792	microsome	RGD:3908	IDA	Rat	RGD:1580491\|PMID:15093748
Cellular Component	GO:0005792	microsome	RGD:3908	IDA	Rat	RGD:1601407\|PMID:12147258
Cellular Component	GO:0043005	neuron projection	RGD:3908	IDA	Rat	RGD:1304444\|PMID:14559897
Cellular Component	GO:0048471	perinuclear region of cytoplasm	RGD:3908	IDA	Rat	RGD:1304444\|PMID:14559897
Cellular Component	GO:0043234	protein complex	RGD:3908	IMP	Rat	RGD:1601406\|PMID:15611338
Cellular Component	GO:0043234	protein complex	RGD:3908	IDA	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0006953	acute-phase response	RGD:3908	IMP	Rat	RGD:625610\|PMID:7651821
Biological Process	GO:0045184	establishment of protein localization	RGD:3908	IMP	Rat	RGD:1580491\|PMID:15093748
Biological Process	GO:0007507	heart development	MGI:102548	IMP	Mouse	MGI:MGI:1333508\|PMID:10096549
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:102548	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	MGI:102548	IGI	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	IMP	Mouse	MGI:MGI:1333508\|PMID:10096549
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	IGI	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	IMP	Mouse	MGI:MGI:1345025\|PMID:10491404
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	IMP	Mouse	MGI:MGI:1858852\|PMID:10827137
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:102548	IGI	Mouse	MGI:MGI:3586938\|PMID:16027168
Biological Process	GO:0008285	negative regulation of cell proliferation	RGD:3908	IMP	Rat	RGD:625610\|PMID:7651821
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	RGD:3908	IDA	Rat	RGD:1580517\|PMID:14612383
Biological Process	GO:0043407	negative regulation of MAP kinase activity	RGD:3908	IMP	Rat	RGD:1580517\|PMID:14612383
Biological Process	GO:0014067	negative regulation of phosphoinositide 3-kinase cascade	MGI:102548	IMP	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0006469	negative regulation of protein kinase activity	MGI:102548	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0051898	negative regulation of protein kinase B signaling cascade	MGI:102548	IMP	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0051898	negative regulation of protein kinase B signaling cascade	MGI:102548	IGI	Mouse	MGI:MGI:3586939\|PMID:16027169
Biological Process	GO:0032007	negative regulation of TOR signaling pathway	RGD:3908	IDA	Rat	RGD:1580520\|PMID:12869586
Biological Process	GO:0030178	negative regulation of Wnt receptor signaling pathway	RGD:3908	IDA	Rat	RGD:1304267\|PMID:12511557
Biological Process	GO:0001843	neural tube closure	MGI:102548	IMP	Mouse	MGI:MGI:1333508\|PMID:10096549
Biological Process	GO:0014065	phosphoinositide 3-kinase cascade	MGI:102548	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0050918	positive chemotaxis	MGI:102548	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0051291	protein heterooligomerization	RGD:3908	IDA	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0051291	protein heterooligomerization	RGD:3908	IMP	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0051260	protein homooligomerization	RGD:3908	IDA	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0051260	protein homooligomerization	RGD:3908	IMP	Rat	RGD:1601351\|PMID:17379185
Biological Process	GO:0006606	protein import into nucleus	MGI:102548	IMP	Mouse	MGI:MGI:1858852\|PMID:10827137
Biological Process	GO:0043491	protein kinase B signaling cascade	MGI:102548	IMP	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0043491	protein kinase B signaling cascade	MGI:102548	IGI	Mouse	MGI:MGI:3050929\|PMID:15249583
Biological Process	GO:0008104	protein localization	MGI:102548	IDA	Mouse	MGI:MGI:2155582\|PMID:11741832
Biological Process	GO:0032956	regulation of actin cytoskeleton organization and biogenesis	RGD:3908	IMP	Rat	RGD:1601406\|PMID:15611338
Biological Process	GO:0030100	regulation of endocytosis	MGI:102548	IMP	Mouse	MGI:MGI:1858852\|PMID:10827137
Biological Process	GO:0051893	regulation of focal adhesion formation	RGD:3908	IMP	Rat	RGD:1601406\|PMID:15611338
Biological Process	GO:0046626	regulation of insulin receptor signaling pathway	MGI:102548	IMP	Mouse	MGI:MGI:2429349\|PMID:12403809
Biological Process	GO:0000074	regulation of progression through cell cycle	RGD:3908	IMP	Rat	RGD:625610\|PMID:7651821
Biological Process	GO:0051492	regulation of stress fiber formation	RGD:3908	IMP	Rat	RGD:1601406\|PMID:15611338
Biological Process	GO:0007165	signal transduction	RGD:3908	IDA	Rat	RGD:625501\|PMID:12045200