Compare GO annotations related to Leigh syndrome, due to COX deficiency using OMIM genes and OrthoDisease orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: mouse, human, rat, worm, fly, dicty, chicken, zfin, rice, tair, yeast, pombe, pfalc, and multiple.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Mouse from MGI; Human from GO Annotations @ EBI (GOA); Rat from RGD; Chicken from GOA; Fly from FlyBase; Pfalc from PlasmoDB; Worm from WormBase; Dicty from dictyBase; Yeast from SGD; Zfin from ZFIN; Tair from TAIR/TIGR; Rice from Gramene; Pombe from Sanger GeneDB.
Does not include evidence codes: IEA, ISS, RCA, NR, ND, NAS, IC, IGC, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
All nodes are linked to the MGI GO browser.
Graph generated Fri Dec 7 14:03:29 2007.

Category	ID	Term	DB Object	Evidence	Organism	Reference
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	MGI:1343135	IDA	Mouse	MGI:MGI:1859526\|PMID:10747996
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	O00217	IMP	Human	PMID:9837812
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	O43181	IMP	Human	PMID:16478720
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	O43181	IMP	Human	PMID:16870178
Molecular Function	GO:0008137	NADH dehydrogenase (ubiquinone) activity	O43181	IMP	Human	PMID:15038602
Molecular Function	GO:0003954	NADH dehydrogenase activity	O75489	IMP	Human	PMID:11112787
Molecular Function	GO:0003954	NADH dehydrogenase activity	O75489	IMP	Human	PMID:16826196
Molecular Function	GO:0003954	NADH dehydrogenase activity	O00217	IMP	Human	PMID:15159508
Molecular Function	GO:0003954	NADH dehydrogenase activity	O00217	IMP	Human	PMID:14749350
Molecular Function	GO:0016653	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	S000000943	IMP	Yeast	SGD_REF:S000059902\|PMID:11248251
Molecular Function	GO:0016653	oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	S000000943	IGI	Yeast	SGD_REF:S000069465\|PMID:11788607
Molecular Function	GO:0008177	succinate dehydrogenase (ubiquinone) activity	S000001631	IMP	Yeast	SGD_REF:S000086932\|PMID:16232921
Molecular Function	GO:0008177	succinate dehydrogenase (ubiquinone) activity	S000001631	IGI	Yeast	SGD_REF:S000086932\|PMID:16232921
Molecular Function	GO:0000104	succinate dehydrogenase activity	P31040	IDA	Human	PMID:7550341
Molecular Function	GO:0051082	unfolded protein binding	S000003344	IMP	Yeast	SGD_REF:S000060745\|PMID:11389896
Cellular Component	GO:0016021	integral to membrane	S000003344	IDA	Yeast	SGD_REF:S000077016\|PMID:15306853
Cellular Component	GO:0005743	mitochondrial inner membrane	MGI:1920112	IDA	Mouse	MGI:MGI:3590069\|PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	MGI:1915599	IDA	Mouse	MGI:MGI:3590069\|PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	MGI:1922656	IDA	Mouse	MGI:MGI:3590069\|PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	MGI:107851	IDA	Mouse	MGI:MGI:3590069\|PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	MGI:1914195	IDA	Mouse	MGI:MGI:3590069\|PMID:12865426
Cellular Component	GO:0005743	mitochondrial inner membrane	S000002783	IDA	Yeast	SGD_REF:S000052579\|PMID:8599931
Cellular Component	GO:0005743	mitochondrial inner membrane	S000000943	IDA	Yeast	SGD_REF:S000048816\|PMID:9228094
Cellular Component	GO:0005743	mitochondrial inner membrane	S000003344	IDA	Yeast	SGD_REF:S000077016\|PMID:15306853
Cellular Component	GO:0005743	mitochondrial inner membrane	S000003344	IDA	Yeast	SGD_REF:S000046510\|PMID:9162072
Cellular Component	GO:0005747	mitochondrial respiratory chain complex I	MGI:1343135	IDA	Mouse	MGI:MGI:1859526\|PMID:10747996
Cellular Component	GO:0005747	mitochondrial respiratory chain complex I	O75489	IDA	Human	PMID:17209039
Cellular Component	GO:0005747	mitochondrial respiratory chain complex I	O00217	IMP	Human	PMID:11112787
Cellular Component	GO:0005747	mitochondrial respiratory chain complex I	P49821	IMP	Human	PMID:11112787
Cellular Component	GO:0005747	mitochondrial respiratory chain complex I	O43181	IMP	Human	PMID:11112787
Cellular Component	GO:0005747	mitochondrial respiratory chain complex I	O43181	IMP	Human	PMID:16478720
Cellular Component	GO:0005739	mitochondrion	MGI:1915599	IDA	Mouse	MGI:MGI:2682130\|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	MGI:1343135	IDA	Mouse	MGI:MGI:2682130\|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	MGI:1922656	IDA	Mouse	MGI:MGI:2682130\|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	MGI:2385079	IDA	Mouse	MGI:MGI:2682130\|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	MGI:107851	IDA	Mouse	MGI:MGI:2682130\|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	O00217	IDA	Human	PMID:9666055
Cellular Component	GO:0005739	mitochondrion	P31040	IDA	Human	PMID:16826196
Cellular Component	GO:0005739	mitochondrion	P31040	IDA	Human	PMID:7550341
Cellular Component	GO:0005739	mitochondrion	S000002783	IDA	Yeast	SGD_REF:S000117178\|PMID:16823961
Cellular Component	GO:0005739	mitochondrion	S000000943	IDA	Yeast	SGD_REF:S000117178\|PMID:16823961
Cellular Component	GO:0005739	mitochondrion	S000001631	IDA	Yeast	SGD_REF:S000117178\|PMID:16823961
Cellular Component	GO:0005739	mitochondrion	S000003344	IDA	Yeast	SGD_REF:S000117178\|PMID:16823961
Biological Process	GO:0009060	aerobic respiration	S000002783	IMP	Yeast	SGD_REF:S000042848\|PMID:1327750
Biological Process	GO:0009060	aerobic respiration	S000003344	IMP	Yeast	SGD_REF:S000046510\|PMID:9162072
Biological Process	GO:0007420	brain development	O43181	IMP	Human	PMID:14765537
Biological Process	GO:0019933	cAMP-mediated signaling	O43181	IMP	Human	PMID:11165261
Biological Process	GO:0019933	cAMP-mediated signaling	O43181	IMP	Human	PMID:11181577
Biological Process	GO:0045333	cellular respiration	O43181	IMP	Human	PMID:16478720
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	S000002783	IMP	Yeast	SGD_REF:S000061850\|PMID:10508156
Biological Process	GO:0051131	chaperone-mediated protein complex assembly	S000002783	IPI	Yeast	SGD_REF:S000061850\|PMID:10508156
Biological Process	GO:0006118	electron transport	P31040	IDA	Human	PMID:7550341
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003061	IMP	Worm	WB:WBPaper00004402\|PMID:11099033
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003831	IMP	Worm	WB:WBPaper00005654\|PMID:12529635
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003831	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003061	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003831	IMP	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003061	IMP	Worm	WB:WBPaper00025054\|PMID:15791247
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	WBGene00003831	IMP	Worm	WB:WBPaper00024944\|PMID:15563610
Biological Process	GO:0040007	growth	WBGene00003061	IMP	Worm	WB:WBPaper00004402\|PMID:11099033
Biological Process	GO:0040007	growth	WBGene00003831	IMP	Worm	WB:WBPaper00005654\|PMID:12529635
Biological Process	GO:0040007	growth	WBGene00003831	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0040007	growth	WBGene00003061	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0006784	heme a biosynthetic process	Q7KZN9	IGI	Human	PMID:12474143
Biological Process	GO:0006784	heme a biosynthetic process	S000000943	IGI	Yeast	SGD_REF:S000069465\|PMID:11788607
Biological Process	GO:0006784	heme a biosynthetic process	S000000943	IMP	Yeast	SGD_REF:S000069465\|PMID:11788607
Biological Process	GO:0006917	induction of apoptosis	O75489	IMP	Human	PMID:16826196
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00003061	IMP	Worm	WB:WBPaper00004402\|PMID:11099033
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00003831	IMP	Worm	WB:WBPaper00005654\|PMID:12529635
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00003831	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0002119	larval development (sensu Nematoda)	WBGene00003061	IMP	Worm	WB:WBPaper00006395\|PMID:14551910
Biological Process	GO:0006120	mitochondrial electron transport, NADH to ubiquinone	WBGene00003831	IMP	Worm	WB:WBPaper00028429\|PMID:16920626
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly	O00217	IMP	Human	PMID:15159508
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly	O00217	IMP	Human	PMID:11112787
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly	O43181	IMP	Human	PMID:15038602
Biological Process	GO:0032981	mitochondrial respiratory chain complex I assembly	O43181	IMP	Human	PMID:11112787
Biological Process	GO:0007005	mitochondrion organization and biogenesis	S000002783	IMP	Yeast	SGD_REF:S000061850\|PMID:10508156
Biological Process	GO:0030308	negative regulation of cell growth	O75489	IMP	Human	PMID:16826196
Biological Process	GO:0006800	oxygen and reactive oxygen species metabolic process	O75489	IMP	Human	PMID:16826196
Biological Process	GO:0006800	oxygen and reactive oxygen species metabolic process	O43181	IMP	Human	PMID:16870178
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	O43181	IMP	Human	PMID:16478720
Biological Process	GO:0040010	positive regulation of growth rate	WBGene00003831	IMP	Worm	WB:WBPaper00024944\|PMID:15563610
Biological Process	GO:0040018	positive regulation of multicellular organism growth	WBGene00003831	IMP	Worm	WB:WBPaper00024944\|PMID:15563610
Biological Process	GO:0001932	regulation of protein amino acid phosphorylation	O43181	IMP	Human	PMID:11165261
Biological Process	GO:0000003	reproduction	WBGene00003831	IMP	Worm	WB:WBPaper00024944\|PMID:15563610
Biological Process	GO:0008535	respiratory chain complex IV assembly	Q7KZN9	IMP	Human	PMID:12474143
Biological Process	GO:0051591	response to cAMP	O43181	IMP	Human	PMID:11165261
Biological Process	GO:0051591	response to cAMP	O43181	IMP	Human	PMID:11181577
Biological Process	GO:0042493	response to drug	WBGene00003831	IMP	Worm	WB:WBPaper00028429\|PMID:16920626
Biological Process	GO:0006979	response to oxidative stress	O00217	IDA	Human	PMID:12857734
Biological Process	GO:0019915	sequestering of lipid	WBGene00003061	IMP	Worm	WB:WBPaper00005707\|PMID:12530969