Compare GO annotations related to Li-Fraumeni syndrome using OMIM genes and OrthoDisease orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: mouse, human, rat, worm, fly, dicty, chicken, zfin, rice, tair, yeast, pombe, pfalc, and multiple.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Mouse from MGI; Human from GO Annotations @ EBI (GOA); Rat from RGD; Chicken from GOA; Fly from FlyBase; Pfalc from PlasmoDB; Worm from WormBase; Dicty from dictyBase; Yeast from SGD; Zfin from ZFIN; Tair from TAIR/TIGR; Rice from Gramene; Pombe from Sanger GeneDB.
Does not include evidence codes: IEA, ISS, RCA, NR, ND, NAS, IC, IGC, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
All nodes are linked to the MGI GO browser.
Graph generated Fri Dec 7 14:03:29 2007.

Category	ID	Term	DB Object	Evidence	Organism	Reference
Molecular Function	GO:0005524	ATP binding	P04637	IDA	Human	PMID:8183576
Molecular Function	GO:0003682	chromatin binding	P04637	IDA	Human	PMID:17599062
Molecular Function	GO:0005507	copper ion binding	P04637	IDA	Human	PMID:7824276
Molecular Function	GO:0004861	cyclin-dependent protein kinase inhibitor activity	P42771	IDA	Human	PMID:8259215
Molecular Function	GO:0003677	DNA binding	MGI:98834	IDA	Mouse	MGI:MGI:3612630\|PMID:16363065
Molecular Function	GO:0003677	DNA binding	MGI:98834	IDA	Mouse	MGI:MGI:2183272\|PMID:12135983
Molecular Function	GO:0003677	DNA binding	MGI:98834	IDA	Mouse	MGI:MGI:3589512\|PMID:16107883
Molecular Function	GO:0003677	DNA binding	MGI:98834	IDA	Mouse	MGI:MGI:1336373\|PMID:10205143
Molecular Function	GO:0000739	DNA strand annealing activity	P04637	IDA	Human	PMID:8183576
Molecular Function	GO:0019899	enzyme binding	P04637	IPI	Human	PMID:15577914
Molecular Function	GO:0019899	enzyme binding	P04637	IPI	Human	PMID:10666337
Molecular Function	GO:0051059	NF-kappaB binding	P42771	IDA	Human	PMID:10353611
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:1336979\|PMID:10329696
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:2176657\|PMID:11799106
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:2178004\|PMID:11900485
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:3053255\|PMID:15364958
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:3583493\|PMID:15989966
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:3578084\|PMID:15735665
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:1336373\|PMID:10205143
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:3603103\|PMID:16151013
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:3529885\|PMID:15678128
Molecular Function	GO:0005515	protein binding	MGI:98834	IPI	Mouse	MGI:MGI:1860990\|PMID:10894779
Molecular Function	GO:0005515	protein binding	Q8N726	IPI	Human	PMID:15989956
Molecular Function	GO:0005515	protein binding	Q8N726	IPI	Human	PMID:17274640
Molecular Function	GO:0005515	protein binding	Q8N726	IPI	Human	PMID:17373842
Molecular Function	GO:0005515	protein binding	Q761V2	IPI	Human	PMID:15782130
Molecular Function	GO:0005515	protein binding	P42771	IPI	Human	PMID:11278317
Molecular Function	GO:0005515	protein binding	RGD:3889	IPI	Rat	RGD:12464630
Molecular Function	GO:0046982	protein heterodimerization activity	P04637	IPI	Human	PMID:10837489
Molecular Function	GO:0019901	protein kinase binding	P42771	IPI	Human	PMID:8259215
Molecular Function	GO:0047485	protein N-terminus binding	P04637	IPI	Human	PMID:11861836
Molecular Function	GO:0003700	transcription factor activity	MGI:98834	IDA	Mouse	MGI:MGI:3619675\|PMID:16098148
Molecular Function	GO:0003700	transcription factor activity	MGI:98834	IDA	Mouse	MGI:MGI:3612718\|PMID:16044147
Molecular Function	GO:0003700	transcription factor activity	MGI:98834	IDA	Mouse	MGI:MGI:2183272\|PMID:12135983
Molecular Function	GO:0003700	transcription factor activity	P04637	IDA	Human	PMID:7587074
Cellular Component	GO:0005737	cytoplasm	MGI:98834	IDA	Mouse	MGI:MGI:2176657\|PMID:11799106
Cellular Component	GO:0005737	cytoplasm	MGI:98834	IDA	Mouse	MGI:MGI:2449362\|PMID:12524542
Cellular Component	GO:0005737	cytoplasm	MGI:98834	IDA	Mouse	MGI:MGI:2178004\|PMID:11900485
Cellular Component	GO:0005737	cytoplasm	P04637	IDA	Human	PMID:7720704
Cellular Component	GO:0005737	cytoplasm	P42771	IDA	Human	PMID:16243918
Cellular Component	GO:0005737	cytoplasm	RGD:3889	IMP	Rat	RGD:1598619\|PMID:16688778
Cellular Component	GO:0005829	cytosol	MGI:98834	IDA	Mouse	MGI:MGI:2176657\|PMID:11799106
Cellular Component	GO:0005626	insoluble fraction	P04637	IDA	Human	PMID:12915590
Cellular Component	GO:0005739	mitochondrion	P04637	IDA	Human	PMID:12667443
Cellular Component	GO:0016363	nuclear matrix	P04637	IDA	Human	PMID:11080164
Cellular Component	GO:0005730	nucleolus	Q8N726	IDA	Human	PMID:17110379
Cellular Component	GO:0005730	nucleolus	P04637	IDA	Human	PMID:12080348
Cellular Component	GO:0005654	nucleoplasm	Q8N726	IDA	Human	PMID:17110379
Cellular Component	GO:0005654	nucleoplasm	P04637	IDA	Human	PMID:12915590
Cellular Component	GO:0005654	nucleoplasm	P04637	IDA	Human	PMID:11080164
Cellular Component	GO:0005634	nucleus	MGI:98834	IDA	Mouse	MGI:MGI:2176657\|PMID:11799106
Cellular Component	GO:0005634	nucleus	MGI:98834	IDA	Mouse	MGI:MGI:2178004\|PMID:11900485
Cellular Component	GO:0005634	nucleus	MGI:98834	IDA	Mouse	MGI:MGI:2449362\|PMID:12524542
Cellular Component	GO:0005634	nucleus	MGI:98834	IDA	Mouse	MGI:MGI:3027643\|PMID:14729462
Cellular Component	GO:0005634	nucleus	P04637	IDA	Human	PMID:7720704
Cellular Component	GO:0005634	nucleus	P04637	IDA	Human	PMID:16507995
Cellular Component	GO:0005634	nucleus	P42771	IDA	Human	PMID:16243918
Cellular Component	GO:0005634	nucleus	RGD:3889	IMP	Rat	RGD:1598619\|PMID:16688778
Cellular Component	GO:0005657	replication fork	MGI:98834	IDA	Mouse	MGI:MGI:3053255\|PMID:15364958
Biological Process	GO:0006915	apoptosis	MGI:98834	IGI	Mouse	MGI:MGI:3511396\|PMID:15485914
Biological Process	GO:0006915	apoptosis	MGI:98834	IDA	Mouse	MGI:MGI:3603971\|PMID:16183742
Biological Process	GO:0008637	apoptotic mitochondrial changes	Q8N726	IMP	Human	PMID:12082630
Biological Process	GO:0006919	caspase activation	Q8N726	IMP	Human	PMID:12082630
Biological Process	GO:0008635	caspase activation via cytochrome c	P04637	IDA	Human	PMID:12667443
Biological Process	GO:0007569	cell aging	P04637	IMP	Human	PMID:12080348
Biological Process	GO:0007050	cell cycle arrest	Q8N726	IMP	Human	PMID:15582998
Biological Process	GO:0007050	cell cycle arrest	P42771	IMP	Human	PMID:16243918
Biological Process	GO:0000075	cell cycle checkpoint	P42771	IMP	Human	PMID:16243918
Biological Process	GO:0042149	cellular response to glucose starvation	P04637	IDA	Human	PMID:14744935
Biological Process	GO:0007417	central nervous system development	MGI:98834	IGI	Mouse	MGI:MGI:3603875\|PMID:16199867
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	MGI:98834	IGI	Mouse	MGI:MGI:3603875\|PMID:16199867
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	MGI:98834	IGI	Mouse	MGI:MGI:3714678\|PMID:17476307
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	MGI:98834	IDA	Mouse	MGI:MGI:2156961\|PMID:11790307
Biological Process	GO:0030330	DNA damage response, signal transduction by p53 class mediator	MGI:98834	IDA	Mouse	MGI:MGI:3032953\|PMID:11884608
Biological Process	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	MGI:98834	IMP	Mouse	MGI:MGI:2675761\|PMID:12952892
Biological Process	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	MGI:98834	IGI	Mouse	MGI:MGI:3714678\|PMID:17476307
Biological Process	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	P04637	IDA	Human	PMID:14654789
Biological Process	GO:0042771	DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	P04637	IDA	Human	PMID:14744935
Biological Process	GO:0006309	DNA fragmentation during apoptosis	Q8N726	IMP	Human	PMID:12082630
Biological Process	GO:0009792	embryonic development ending in birth or egg hatching	MGI:98834	IGI	Mouse	MGI:MGI:3624572\|PMID:16702401
Biological Process	GO:0006983	ER overload response	P04637	IDA	Human	PMID:14744935
Biological Process	GO:0031571	G1 DNA damage checkpoint	MGI:98834	IMP	Mouse	MGI:MGI:3589512\|PMID:16107883
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle	P42771	IDA	Human	PMID:10208428
Biological Process	GO:0001701	in utero embryonic development	MGI:98834	IGI	Mouse	MGI:MGI:1096207\|PMID:9288110
Biological Process	GO:0006917	induction of apoptosis	MGI:98834	IDA	Mouse	MGI:MGI:3589512\|PMID:16107883
Biological Process	GO:0006917	induction of apoptosis	MGI:98834	IMP	Mouse	MGI:MGI:3700903\|PMID:17210642
Biological Process	GO:0006917	induction of apoptosis	Q8N726	IMP	Human	PMID:12082630
Biological Process	GO:0006917	induction of apoptosis	P42771	IDA	Human	PMID:10208428
Biological Process	GO:0032088	inhibition of NF-kappaB transcription factor	P42771	IDA	Human	PMID:10353611
Biological Process	GO:0007275	multicellular organismal development	P04637	IMP	Human	PMID:10065150
Biological Process	GO:0043066	negative regulation of apoptosis	MGI:98834	IMP	Mouse	MGI:MGI:2675761\|PMID:12952892
Biological Process	GO:0030308	negative regulation of cell growth	P04637	IMP	Human	PMID:8986812
Biological Process	GO:0030308	negative regulation of cell growth	P42771	IDA	Human	PMID:10208428
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:98834	IGI	Mouse	MGI:MGI:1350531\|PMID:10591652
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:98834	IGI	Mouse	MGI:MGI:1350533\|PMID:10591653
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:98834	IGI	Mouse	MGI:MGI:2445783\|PMID:11246230
Biological Process	GO:0008285	negative regulation of cell proliferation	MGI:98834	IGI	Mouse	MGI:MGI:1889141\|PMID:10973261
Biological Process	GO:0008285	negative regulation of cell proliferation	P42771	IMP	Human	PMID:16243918
Biological Process	GO:0001953	negative regulation of cell-matrix adhesion	P42771	IMP	Human	PMID:10205165
Biological Process	GO:0045736	negative regulation of cyclin-dependent protein kinase activity	P42771	IDA	Human	PMID:8259215
Biological Process	GO:0008156	negative regulation of DNA replication	MGI:98834	IDA	Mouse	MGI:MGI:3032953\|PMID:11884608
Biological Process	GO:0008156	negative regulation of DNA replication	MGI:98834	IMP	Mouse	MGI:MGI:3032953\|PMID:11884608
Biological Process	GO:0048147	negative regulation of fibroblast proliferation	MGI:98834	IMP	Mouse	MGI:MGI:2675761\|PMID:12952892
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	MGI:98834	IGI	Mouse	MGI:MGI:1203920\|PMID:9608530
Biological Process	GO:0042326	negative regulation of phosphorylation	P42771	IDA	Human	PMID:10208428
Biological Process	GO:0042326	negative regulation of phosphorylation	P42771	IDA	Human	PMID:8259215
Biological Process	GO:0006469	negative regulation of protein kinase activity	Q8N726	IMP	Human	PMID:15582998
Biological Process	GO:0006289	nucleotide-excision repair	P04637	IMP	Human	PMID:7663514
Biological Process	GO:0043065	positive regulation of apoptosis	RGD:3889	IMP	Rat	RGD:1598619\|PMID:16688778
Biological Process	GO:0043525	positive regulation of neuron apoptosis	MGI:98834	IMP	Mouse	MGI:MGI:1203920\|PMID:9608530
Biological Process	GO:0043525	positive regulation of neuron apoptosis	MGI:98834	IDA	Mouse	MGI:MGI:1860990\|PMID:10894779
Biological Process	GO:0043525	positive regulation of neuron apoptosis	MGI:98834	IMP	Mouse	MGI:MGI:3574697\|PMID:15483136
Biological Process	GO:0043525	positive regulation of neuron apoptosis	MGI:98834	IGI	Mouse	MGI:MGI:1860400\|PMID:10911993
Biological Process	GO:0045941	positive regulation of transcription	MGI:98834	IDA	Mouse	MGI:MGI:3578084\|PMID:15735665
Biological Process	GO:0045941	positive regulation of transcription	MGI:98834	IGI	Mouse	MGI:MGI:3578084\|PMID:15735665
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:98834	IDA	Mouse	MGI:MGI:3589512\|PMID:16107883
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	MGI:98834	IDA	Mouse	MGI:MGI:3619675\|PMID:16098148
Biological Process	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	P04637	IDA	Human	PMID:17599062
Biological Process	GO:0045893	positive regulation of transcription, DNA-dependent	MGI:98834	IDA	Mouse	MGI:MGI:3612718\|PMID:16044147
Biological Process	GO:0006461	protein complex assembly	P04637	IDA	Human	PMID:12915590
Biological Process	GO:0000060	protein import into nucleus, translocation	MGI:98834	IDA	Mouse	MGI:MGI:2176657\|PMID:11799106
Biological Process	GO:0008104	protein localization	P04637	IDA	Human	PMID:16507995
Biological Process	GO:0042981	regulation of apoptosis	P04637	IDA	Human	PMID:14744935
Biological Process	GO:0042127	regulation of cell proliferation	MGI:98834	IMP	Mouse	MGI:MGI:2670239\|PMID:12878730
Biological Process	GO:0010389	regulation of G2/M transition of mitotic cell cycle	Q8N726	IMP	Human	PMID:15582998
Biological Process	GO:0051453	regulation of intracellular pH	RGD:3889	IMP	Rat	RGD:1598619\|PMID:16688778
Biological Process	GO:0043523	regulation of neuron apoptosis	MGI:98834	IGI	Mouse	MGI:MGI:3574697\|PMID:15483136
Biological Process	GO:0000074	regulation of progression through cell cycle	MGI:98834	IMP	Mouse	MGI:MGI:3583041\|PMID:15898111
Biological Process	GO:0006355	regulation of transcription, DNA-dependent	MGI:98834	IDA	Mouse	MGI:MGI:2183272\|PMID:12135983
Biological Process	GO:0006355	regulation of transcription, DNA-dependent	P04637	IDA	Human	PMID:7587074
Biological Process	GO:0001836	release of cytochrome c from mitochondria	MGI:98834	IDA	Mouse	MGI:MGI:3574697\|PMID:15483136
Biological Process	GO:0006974	response to DNA damage stimulus	MGI:98834	IDA	Mouse	MGI:MGI:3057054\|PMID:15383658
Biological Process	GO:0006974	response to DNA damage stimulus	MGI:98834	IMP	Mouse	MGI:MGI:2675761\|PMID:12952892
Biological Process	GO:0006974	response to DNA damage stimulus	MGI:98834	IDA	Mouse	MGI:MGI:3032464\|PMID:14744935
Biological Process	GO:0006974	response to DNA damage stimulus	P04637	IEP	Human	PMID:8986812
Biological Process	GO:0010332	response to gamma radiation	MGI:98834	IDA	Mouse	MGI:MGI:3032464\|PMID:14744935
Biological Process	GO:0009411	response to UV	MGI:98834	IMP	Mouse	MGI:MGI:2675761\|PMID:12952892
Biological Process	GO:0009411	response to UV	MGI:98834	IDA	Mouse	MGI:MGI:3032464\|PMID:14744935
Biological Process	GO:0010165	response to X-ray	MGI:98834	IDA	Mouse	MGI:MGI:3032953\|PMID:11884608
Biological Process	GO:0010149	senescence	Q8N726	IMP	Human	PMID:14966292
Biological Process	GO:0010149	senescence	P42771	IMP	Human	PMID:14720514