Compare GO annotations related to Amyotrophic lateral sclerosis, due to SOD1 deficiency using OMIM genes and OrthoDisease orthologs

A table of the annotations represented in this image is provided below.

Annotations are indicated by colored nodes: mouse, human, rat, worm, fly, dicty, chicken, zfin, rice, tair, yeast, pombe, pfalc, and multiple.
Green arrows indicate "is_a"; Purple arrows indicate "part_of"
GO annotations: Mouse from MGI; Human from GO Annotations @ EBI (GOA); Rat from RGD; Chicken from GOA; Fly from FlyBase; Pfalc from PlasmoDB; Worm from WormBase; Dicty from dictyBase; Yeast from SGD; Zfin from ZFIN; Tair from TAIR/TIGR; Rice from Gramene; Pombe from Sanger GeneDB.
Does not include evidence codes: IEA, ISS, RCA, NR, ND, NAS, IC, IGC, TAS.
Graph is also available as SVG (requires viewer plug-in from Adobe)
All nodes are linked to the MGI GO browser.
Graph generated Fri Dec 7 14:03:29 2007.

Category	ID	Term	DB Object	Evidence	Organism	Reference
Molecular Function	GO:0051087	chaperone binding	P00441	IPI	Human	PMID:9726962
Molecular Function	GO:0051087	chaperone binding	RGD:3731	IMP	Rat	RGD:634854\|PMID:12514262
Molecular Function	GO:0005507	copper ion binding	P00441	IDA	Human	PMID:17008312
Molecular Function	GO:0005507	copper ion binding	RGD:3731	IMP	Rat	RGD:634854\|PMID:12514262
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:1201750\|PMID:9516486
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:1314762\|PMID:9788901
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:3625573\|PMID:12433839
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:2682495\|PMID:14679182
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:80951\|PMID:8673102
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:3624710\|PMID:16716900
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:1353351\|PMID:10679476
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IDA	Mouse	MGI:MGI:2655950\|PMID:12646716
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:1351737\|PMID:10471451
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:2136726\|PMID:11404260
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	P00441	IDA	Human	PMID:17324120
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	P00441	IDA	Human	PMID:15544046
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	RGD:3731	IDA	Rat	RGD:730094\|PMID:2703531
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	RGD:3731	IDA	Rat	RGD:1601266\|PMID:10640619
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	RGD:3731	IDA	Rat	RGD:634854\|PMID:12514262
Molecular Function	GO:0004785	copper, zinc superoxide dismutase activity	S000003865	IDA	Yeast	SGD_REF:S000057058\|PMID:3290902
Molecular Function	GO:0005515	protein binding	MGI:98351	IPI	Mouse	MGI:MGI:77968\|PMID:2960971
Molecular Function	GO:0005515	protein binding	RGD:3731	IMP	Rat	RGD:634854\|PMID:12514262
Molecular Function	GO:0030346	protein phosphatase 2B binding	P00441	IDA	Human	PMID:17324120
Molecular Function	GO:0004784	superoxide dismutase activity	MGI:98351	IDA	Mouse	MGI:MGI:3608389\|PMID:12968068
Molecular Function	GO:0004784	superoxide dismutase activity	MGI:98351	IDA	Mouse	MGI:MGI:54701\|PMID:291939
Molecular Function	GO:0004784	superoxide dismutase activity	MGI:98351	IMP	Mouse	MGI:MGI:1342989\|PMID:10436316
Molecular Function	GO:0004784	superoxide dismutase activity	MGI:98351	IDA	Mouse	MGI:MGI:3522379\|PMID:15317809
Molecular Function	GO:0008270	zinc ion binding	P00441	IDA	Human	PMID:17381088
Cellular Component	GO:0043025	cell soma	P00441	IDA	Human	PMID:17324120
Cellular Component	GO:0043025	cell soma	RGD:3731	IDA	Rat	RGD:1601266\|PMID:10640619
Cellular Component	GO:0005737	cytoplasm	P00441	IDA	Human	PMID:17504823
Cellular Component	GO:0005737	cytoplasm	P00441	IDA	Human	PMID:9726962
Cellular Component	GO:0005737	cytoplasm	P00441	IDA	Human	PMID:11527942
Cellular Component	GO:0005737	cytoplasm	P00441	IDA	Human	PMID:17077646
Cellular Component	GO:0005737	cytoplasm	RGD:3731	IDA	Rat	RGD:1581086\|PMID:16372329
Cellular Component	GO:0031410	cytoplasmic vesicle	P00441	IDA	Human	PMID:17077646
Cellular Component	GO:0005829	cytosol	P00441	IDA	Human	PMID:16790527
Cellular Component	GO:0005829	cytosol	S000003865	IDA	Yeast	SGD_REF:S000068943\|PMID:11500508
Cellular Component	GO:0032839	dendrite cytoplasm	P00441	IDA	Human	PMID:17324120
Cellular Component	GO:0031012	extracellular matrix	P00441	IDA	Human	PMID:9699963
Cellular Component	GO:0005615	extracellular space	MGI:98351	IDA	Mouse	MGI:MGI:3574179\|PMID:15634772
Cellular Component	GO:0005615	extracellular space	P00441	IDA	Human	PMID:7172448
Cellular Component	GO:0005615	extracellular space	P00441	IDA	Human	PMID:9453566
Cellular Component	GO:0005758	mitochondrial intermembrane space	S000003865	IDA	Yeast	SGD_REF:S000068943\|PMID:11500508
Cellular Component	GO:0005739	mitochondrion	MGI:98351	IDA	Mouse	MGI:MGI:2682130\|PMID:14651853
Cellular Component	GO:0005739	mitochondrion	P00441	IDA	Human	PMID:16790527
Cellular Component	GO:0005739	mitochondrion	RGD:3731	IDA	Rat	RGD:1581088\|PMID:16337891
Cellular Component	GO:0005739	mitochondrion	S000003865	IDA	Yeast	SGD_REF:S000117178\|PMID:16823961
Cellular Component	GO:0005634	nucleus	P00441	IDA	Human	PMID:17504823
Cellular Component	GO:0005634	nucleus	P00441	IDA	Human	PMID:9726962
Cellular Component	GO:0005634	nucleus	RGD:3731	IDA	Rat	RGD:1581086\|PMID:16372329
Cellular Component	GO:0005886	plasma membrane	P00441	IDA	Human	PMID:17077646
Cellular Component	GO:0005886	plasma membrane	P00441	IDA	Human	PMID:17324120
Cellular Component	GO:0043234	protein complex	P00441	IDA	Human	PMID:17324120
Biological Process	GO:0000187	activation of MAPK activity	MGI:98351	IDA	Mouse	MGI:MGI:2387280\|PMID:12223545
Biological Process	GO:0001320	age-dependent response to reactive oxygen species during chronological cell aging	S000003865	IMP	Yeast	SGD_REF:S000057859\|PMID:8647826
Biological Process	GO:0007568	aging	MGI:98351	IMP	Mouse	MGI:MGI:3640408\|PMID:16377630
Biological Process	GO:0006916	anti-apoptosis	RGD:3731	IMP	Rat	RGD:1581094\|PMID:11961082
Biological Process	GO:0060088	auditory receptor cell stereocilium organization and biogenesis	MGI:98351	IMP	Mouse	MGI:MGI:3700629\|PMID:10464373
Biological Process	GO:0060088	auditory receptor cell stereocilium organization and biogenesis	MGI:98351	IMP	Mouse	MGI:MGI:1344578\|PMID:10466888
Biological Process	GO:0007569	cell aging	P00441	IMP	Human	PMID:12871978
Biological Process	GO:0007569	cell aging	P00441	IEP	Human	PMID:15377661
Biological Process	GO:0006878	cellular copper ion homeostasis	S000003865	IGI	Yeast	SGD_REF:S000049199\|PMID:8530401
Biological Process	GO:0006879	cellular iron ion homeostasis	MGI:98351	IMP	Mouse	MGI:MGI:3640408\|PMID:16377630
Biological Process	GO:0006882	cellular zinc ion homeostasis	S000003865	IGI	Yeast	SGD_REF:S000066265\|PMID:11581253
Biological Process	GO:0006882	cellular zinc ion homeostasis	S000003865	IMP	Yeast	SGD_REF:S000066265\|PMID:11581253
Biological Process	GO:0006309	DNA fragmentation during apoptosis	MGI:98351	IDA	Mouse	MGI:MGI:2387280\|PMID:12223545
Biological Process	GO:0006302	double-strand break repair	MGI:98351	IMP	Mouse	MGI:MGI:3691744\|PMID:15642323
Biological Process	GO:0007566	embryo implantation	MGI:98351	IMP	Mouse	MGI:MGI:1201750\|PMID:9516486
Biological Process	GO:0006749	glutathione metabolic process	MGI:98351	IMP	Mouse	MGI:MGI:3640408\|PMID:16377630
Biological Process	GO:0060047	heart contraction	MGI:98351	IMP	Mouse	MGI:MGI:1353351\|PMID:10679476
Biological Process	GO:0060047	heart contraction	P00441	IDA	Human	PMID:9539776
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	MGI:98351	IMP	Mouse	MGI:MGI:2682495\|PMID:14679182
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	P00441	IDA	Human	PMID:15544046
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	RGD:3731	IMP	Rat	RGD:1581090\|PMID:15880490
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	RGD:3731	IDA	Rat	RGD:1601266\|PMID:10640619
Biological Process	GO:0050665	hydrogen peroxide biosynthetic process	RGD:3731	IDA	Rat	RGD:634854\|PMID:12514262
Biological Process	GO:0007626	locomotory behavior	MGI:98351	IMP	Mouse	MGI:MGI:1344528\|PMID:10433959
Biological Process	GO:0046716	muscle maintenance	MGI:98351	IMP	Mouse	MGI:MGI:3624710\|PMID:16716900
Biological Process	GO:0032287	myelin maintenance in the peripheral nervous system	MGI:98351	IMP	Mouse	MGI:MGI:1344528\|PMID:10433959
Biological Process	GO:0002262	myeloid cell homeostasis	MGI:98351	IGI	Mouse	MGI:MGI:2149223\|PMID:11493445
Biological Process	GO:0002262	myeloid cell homeostasis	MGI:98351	IMP	Mouse	MGI:MGI:2149223\|PMID:11493445
Biological Process	GO:0043066	negative regulation of apoptosis	MGI:98351	IMP	Mouse	MGI:MGI:3688805\|PMID:16036348
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process	P00441	IDA	Human	PMID:15473258
Biological Process	GO:0043524	negative regulation of neuron apoptosis	MGI:98351	IMP	Mouse	MGI:MGI:3700629\|PMID:10464373
Biological Process	GO:0060052	neurofilament cytoskeleton organization and biogenesis	MGI:98351	IMP	Mouse	MGI:MGI:1934092\|PMID:11343650
Biological Process	GO:0060052	neurofilament cytoskeleton organization and biogenesis	MGI:98351	IGI	Mouse	MGI:MGI:1934092\|PMID:11343650
Biological Process	GO:0001541	ovarian follicle development	MGI:98351	IMP	Mouse	MGI:MGI:1889068\|PMID:9724058
Biological Process	GO:0043085	positive regulation of catalytic activity	P00441	IDA	Human	PMID:17324120
Biological Process	GO:0001819	positive regulation of cytokine production	P00441	IDA	Human	PMID:15544046
Biological Process	GO:0008217	regulation of blood pressure	MGI:98351	IMP	Mouse	MGI:MGI:3625573\|PMID:12433839
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	P00441	IMP	Human	PMID:16790527
Biological Process	GO:0040014	regulation of multicellular organism growth	MGI:98351	IMP	Mouse	MGI:MGI:3640408\|PMID:16377630
Biological Process	GO:0045859	regulation of protein kinase activity	P00441	IDA	Human	PMID:16254550
Biological Process	GO:0060087	relaxation of vascular smooth muscle	MGI:98351	IMP	Mouse	MGI:MGI:3625573\|PMID:12433839
Biological Process	GO:0060087	relaxation of vascular smooth muscle	MGI:98351	IMP	Mouse	MGI:MGI:2682495\|PMID:14679182
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:1201750\|PMID:9516486
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:1342989\|PMID:10436316
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:1353351\|PMID:10679476
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:1314762\|PMID:9788901
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:1351737\|PMID:10471451
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IGI	Mouse	MGI:MGI:2149223\|PMID:11493445
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:2149223\|PMID:11493445
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:3710732\|PMID:17448893
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:3625573\|PMID:12433839
Biological Process	GO:0019430	removal of superoxide radicals	MGI:98351	IMP	Mouse	MGI:MGI:80951\|PMID:8673102
Biological Process	GO:0019430	removal of superoxide radicals	RGD:3731	IDA	Rat	RGD:1601266\|PMID:10640619
Biological Process	GO:0019430	removal of superoxide radicals	RGD:3731	IDA	Rat	RGD:634854\|PMID:12514262
Biological Process	GO:0048678	response to axon injury	MGI:98351	IMP	Mouse	MGI:MGI:80951\|PMID:8673102
Biological Process	GO:0009409	response to cold	S000003865	IEP	Yeast	SGD_REF:S000073700\|PMID:12859956
Biological Process	GO:0046688	response to copper ion	RGD:3731	IMP	Rat	RGD:1581098\|PMID:14747682
Biological Process	GO:0042493	response to drug	MGI:98351	IMP	Mouse	MGI:MGI:3692725\|PMID:16831125
Biological Process	GO:0042493	response to drug	S000003865	IMP	Yeast	SGD_REF:S000086944\|PMID:16234568
Biological Process	GO:0045471	response to ethanol	MGI:98351	IMP	Mouse	MGI:MGI:3710732\|PMID:17448893
Biological Process	GO:0009408	response to heat	MGI:98351	IMP	Mouse	MGI:MGI:3688941\|PMID:16942767
Biological Process	GO:0042542	response to hydrogen peroxide	MGI:98351	IMP	Mouse	MGI:MGI:3691744\|PMID:15642323
Biological Process	GO:0031667	response to nutrient levels	RGD:3731	IDA	Rat	RGD:628320\|PMID:12067840
Biological Process	GO:0006979	response to oxidative stress	MGI:98351	IMP	Mouse	MGI:MGI:3624710\|PMID:16716900
Biological Process	GO:0006979	response to oxidative stress	MGI:98351	IMP	Mouse	MGI:MGI:3699763\|PMID:17059387
Biological Process	GO:0006979	response to oxidative stress	MGI:98351	IDA	Mouse	MGI:MGI:2387280\|PMID:12223545
Biological Process	GO:0006979	response to oxidative stress	P00441	IEP	Human	PMID:17512922
Biological Process	GO:0006979	response to oxidative stress	P00441	IEP	Human	PMID:15377661
Biological Process	GO:0000302	response to reactive oxygen species	MGI:98351	IMP	Mouse	MGI:MGI:3699763\|PMID:17059387
Biological Process	GO:0000303	response to superoxide	MGI:98351	IMP	Mouse	MGI:MGI:1201750\|PMID:9516486
Biological Process	GO:0000303	response to superoxide	MGI:98351	IMP	Mouse	MGI:MGI:1314762\|PMID:9788901
Biological Process	GO:0000303	response to superoxide	MGI:98351	IMP	Mouse	MGI:MGI:3611643\|PMID:16357131
Biological Process	GO:0000303	response to superoxide	P00441	IDA	Human	PMID:16790527
Biological Process	GO:0001895	retinal homeostasis	MGI:98351	IMP	Mouse	MGI:MGI:3654862\|PMID:16844785
Biological Process	GO:0007605	sensory perception of sound	MGI:98351	IMP	Mouse	MGI:MGI:3607480\|PMID:16055286
Biological Process	GO:0007605	sensory perception of sound	MGI:98351	IMP	Mouse	MGI:MGI:3700629\|PMID:10464373
Biological Process	GO:0007605	sensory perception of sound	MGI:98351	IMP	Mouse	MGI:MGI:1342989\|PMID:10436316
Biological Process	GO:0007283	spermatogenesis	MGI:98351	IMP	Mouse	MGI:MGI:3688805\|PMID:16036348
Biological Process	GO:0006801	superoxide metabolic process	MGI:98351	IMP	Mouse	MGI:MGI:2136726\|PMID:11404260
Biological Process	GO:0006801	superoxide metabolic process	RGD:3731	IDA	Rat	RGD:1601266\|PMID:10640619
Biological Process	GO:0006801	superoxide metabolic process	RGD:3731	IDA	Rat	RGD:634854\|PMID:12514262
Biological Process	GO:0006801	superoxide metabolic process	S000003865	IMP	Yeast	SGD_REF:S000057058\|PMID:3290902
Biological Process	GO:0042554	superoxide release	MGI:98351	IDA	Mouse	MGI:MGI:3522379\|PMID:15317809
Biological Process	GO:0019226	transmission of nerve impulse	MGI:98351	IMP	Mouse	MGI:MGI:1344528\|PMID:10433959