Caution: These are Prototype Reports for Evaluation Purposes Only!

MGD Full QTL Report

J# 25748 Messer et al. 1995

Phenotype Information for J25748

• Phenotype Class: Disease
  
• Phenotype Mode: Spontaneous
  
  • Induced by:NULL
• Phenotype Name: Adult-onset hereditary neurological degeneration
  
  • Phenotype Trait 1: neurological degeneration
    
  • Phenotype Assessment: semi-quantitative
    
• Alternative Keywords: neronal ceroid lipofuscinosis, NCL, motor neuron degeneration, retinal degeneration
  
• Strain/Progenitor Information:
  
  • Strain 1:C57BL/6.KB2-mnd MSr
    
  • Strain 1 Comment:NULL
    
  • Strain 2:AKR/J
    
  • Strain 2 Comment:NULL
    
• Phenotype Comments:NULL
  

Progeny Population for J25748

• Progeny Generation Used for QTL Experiment: F2
• Progeny Population Symbol: NULL
• # Animals Evaluated: 49
• Female Parent:(C57BL/6.KB2-mnd X AKR/J)F1
• Male Parent: (C57BL/6.KB2-mnd X AKR/J)F1
• Cross type: intercross
• Another Mapping Cross for this Progeny: Yes
• Female Parent: (AKR/J X C57BL/6.KB2-mnd)F1
• Male Parent: (AKR/J X C57BL/6.KB2-mnd)F1
• Cross Type: Intercross
• Comments:
  
  • 1)mutant mice of both sexes used to generate F1 stocks
    

Methods for J25748

• Chromosomes Used for Marker Map Construction: All
• Marker Map Methods:
  • Proviral insertion sites
  • PCR-Microsatellites
• Number of Markers in Analysis: NULL
• Intermarker Distance: NULL
• Comments on Marker Map:NULL
• QTL Detection Method:NULL
• Significance Threshold for QTL Detection:NULL
  • Significance Threshold Comment:NULL
• QTL Estimation Method: interval mapping
• Comments on QTL Estimation Model Used: NULL
• QTL Mapping Software: MapMaker

QTL Information for J25748

Phenotype Trait: Onset/timing of neurological degeneration

QTL Symbol: Unnamed

• QTL Detection Method: Chi-square Contingency tests
• Table of Linked Markers:

  QTL Symbol	Linked Marker Symbol	Association Score	P Value	Chromosome
  Unnamed	D1Mit65	NULL	< 0.0442	1
  Unnamed	D1Mit3	NULL	< 0.0258	1
  Unnamed	D1Mit173	NULL	< 0.0114	1
  Unnamed	D1Mit232	NULL	< 0.0114	1
  Unnamed	D1Mit18	NULL	< 0.0114	1
  Unamed	D1Mit22	NULL	< 0.0171	1

• QTL Estimation: Chromosome 1
  • Chromosome: 1
  • Location: proximal half
  • % Phenotypic Variation Accounted For: NULL
  • Confidence Interval for QTL Estimation: NULL
• Comments:NULL

Candidate Genes for QTLs Reported in J25748

• Comments:NULL

Overall Comments for J25748

• 1) Age of onset and timing of disease development hypothesized to be due to 2 or 3 unlinked dominant genes with incomplete penetrance at any locus.
• 2) No differences in onset observed between males and females.
• 3) Contributions of loci on chromosomes 5 and 10 being investigated.
• 4) Accumulation of lipopigment and retinal degeneration do not appear to be associated with the genes involved in the timing affect of neurological disease.
• 5) mnd mice do not appear to be genocopies of either of the mapped forms of NCL.

Back to QTL Summary Table