The Mammalian Phenotype (MP) Ontology is a community effort to provide standard terms for annotating phenotypic data. You can use this browser to view terms, definitions, and term relationships in a hierarchical display. Links to summary annotated phenotype data at MGI are provided in Term Detail reports.
This help document answers the following questions about the MP Browser:
The Mammalian Phenotype Ontology has a hierarchical structure that permits a range of detail from high-level, broadly descriptive terms to very low-level, highly specific terms. This range is useful for annotating phenotypic data to the level of detail known and for searching for this information using either broad or specific terms as search criteria. Organizing the phenotype terms as a Directed Acyclic Graph (DAG), i.e., in which a term can have more than one parent, allows presentation of phenotypes from multiple perspectives.
Use the Browser to find vocabulary terms that may be used in annotations of phenotypic data. You can choose a term or MP ID here to improve your searches with the Phenotype/Disease box on the Phenotypes, Alleles, & Disease Models and Genes and Markers Query Forms as well as the appropriate fields on the Gene Expression Data Query and Human - Mouse: Disease Connection forms. Selected terms in the Phenotype Tree View link to a listing of all genotypes annotated to the term and it descendants.
You can either browse or search from the MP Browser entry report. You can browse by clicking on terms in the Phenotype Tree View. This shows a term's place in the hierarchy, provides links to all genotypes annotated to a selected term, and updates the Phenotype Term Detail section of the page with the selected term's parent terms, ID, definition, and any synonyms associated with the phenotype term. Searching requires entering a text string in the Phenotype Search box. This brings up an autocomplete list displaying all matches.
To browse the vocabulary, click a term in the Tree View or a parent term in the Term Detail section until you find the desired phenotypic term. A small white triangle at the beginning of a term indicates the term has subterms. You can expand branches by clicking on a term or its preceding white triangle. If you click on a term, this also updates the Phenotype Term Detail section. You can collapse branches by clicking on the small black triangle. You can click on the triangles to navigate the branches without updating the Term Detail section. You can copy term IDs into the Phenotypes/Disease box on the Phenotypes, Alleles, & Disease Models Query Form to search for data associated with this term.
The Phenotype Search field accepts any text string and searches for all terms containing that string and any synonyms. To do this:
The first term listed in your search results is automatically selected and updates the Phenotype Term Detail and Phenotype Tree View sections on the right. Click on a different term in your search results to refresh the Phentype Term Detail and Tree View with the selected phenotype. Use the Clear button to start a new search.
|Phenotype Search||The search finds all phenotype terms that contain all of your search terms and displays a ranked list of those terms. Click on a term to update the Phenotype Term Detail and Tree View sections of the page with the appropriate phenotypes and the selected term highlighted in blue.|
|Phenotype Term Detail||
|Phenotype Tree View||The main phenotype headings are shown beneath the section header. The number of genotypes/annotations to the selected term is shown. Child terms are shown beneath the selected term in the tree view. You can collapse or expand branches by clicking on a triangle. When you select a new term, it is highlighted in blue and the Term Detail section is updated.
Click on the number of genotypes/annotations for a listing of all the genotypes annotated to the term.
|"Is-a" Relationship||Indicates that the term is an instance or type of the more general term above it in the tree. For example, anophthalmia is a type of eye abnormality.|
|A small white triangle preceding a term in the Tree View indicates that the term has children. Click on the white triangle to see the additional paths. You can collapse branches by clicking on the small black triangle.|
|# genotypes, # annotations||Number of genotypes annotated to the term and its descendants, followed by the number of annotations to each term and its descendants. Click this label to see the Mammalian Phenotype Ontology Annotations Query Results.|
The summary report presents a list of MGI genotypes annotated to a term or its descendants. You access this report by clicking the text displaying the number of genotypes and annotations for a featured term in the MP browser or the number of phenotypes in the Mutations, Alleles, and Phenotypes section of a Gene Detail page. Depending upon how you reached the results, you may be offered the option of exporting the results in a spreadsheet format.
|Genotype/Allelic Composition (Genetic Background)||The genotype composed of the mutation, linked to the MGI Allele Detail report, and the mouse strain background.|
|Annotated Term||Specific MP term used to describe the given genotype, linked to its Mammalian Phenotype Ontology Term Detail report.|
|Reference||A listing of the supporting MGI references, linked to the References Detail report containing the full citation, with links to the Journal (if available) and data curated from the reference.|
Your input is welcome. Additional terms or revisions may be requested through our tracking system at Sourceforge. Please contact us with suggestions, additions, or questions about the Mammalian Phenotype Ontology.