The Anatomy Ontology for the Adult Mouse was developed and is being refined to provide standardized nomenclature for anatomical structures in the postnatal mouse (Theiler stage 28).
Use the Adult Mouse Anatomy Browser to view the anatomical terms and their relationships in a hierarchical display.
This help document answers the following questions about the Browser:
The Anatomy Ontology for the Adult Mouse is organized spatially and functionally, using "is a" and "part of" relationships. Anatomical terms are arranged as a hierarchy from body region or organ system to tissue substructure.
Modeling the anatomy hierarchically makes it possible to record expression results from assays with differing spatial resolution in a consistent and integrated manner. Organizing the anatomical terms as a Directed Acyclic Graph (DAG), i.e., in which a term can have more than one parent, allows presentation of the anatomy from multiple perspectives.
Use the Browser to find standardized vocabulary terms for anatomical structures present in the postnatal mouse (Theiler stage 28).
To browse the vocabulary, click on terms in the Anatomy Tree View on the Adult Mouse Anatomy Browser page. This shows a term's place in the hierarchy, and updates the Adult Anatomy Term Detail section of the page with the selected term's parent terms (superstructures) and ID. Click on structures to navigate progressively through the ontology in order to locate specific anatomical terms. In the Anatomical Tree View a small white triangle at the beginning of a term indicates the term has subterms. You can expand branches by clicking on a term or its preceding white triangle. If you click on a term, this also updates the Anatomical Term Detail section. You can collapse branches by clicking on the small black triangle. You can click on the triangles to navigate the branches without updating the Term Detail section.
The Anatomy Search field accepts any text string and searches for all terms containing that string plus any synonyms. You can search by anatomy term to determine where a particular structure exists in the Adult Anatomy Ontology and see, in the Anatomical Tree View section, the anatomy hierarchy. To do this:
The first term listed in your search results is automatically selected and updates the Anatomical Term Detail and Anatomical Tree View sections on the right. Click on a different term in your search results to refresh the Anatomical Term Detail and Tree View with the selected structure and developmental stages. Use the Clear button to start a new search.
|Anatomy Search||The search finds all structures that contain any of your search terms and displays a ranked list of those structures. Click on a term to update the Anatomical Term Detail and Tree View sections of the page with the selected term highlighted in gold.|
|Anatomical Term Detail||
|Anatomical Tree View||You can collapse or expand branches by clicking on a term. A small white triangle at the beginning of a term indicates the term has substructures. When you select a new term, it is highlighted in blue and the Term Detail section is updated.|
|"Is-a" Relationship||Indicates that the term is an instance or type of the more general term (parent or superstructure) above it in the hierarchy.|
|"Part-of" Relationship||Indicates that the term is a component of the more general term (parent or superstructure) above it in the hierarchy.|
|A small white triangle preceding a term in the Tree View indicates that the term has substructures. Click on the term to see the additional structures. You can collapse branches by clicking on the small black triangle.|
Your input is welcome. Please contact us with suggestions, additions, or questions about the Adult Mouse Anatomy Ontology.
Terry Hayamizu, Mary Mangan, John Corradi, and Martin Ringwald developed the Adult Mouse Anatomy Ontology as part of the Gene Expression Database (GXD) project. GXD is funded by NIH grant HD062499. Postdoctoral fellowships F32 HD08435-01 and F32 HG00215-01 supported M.M. and J.C.