This help document answers the following questions about the Vertebrate Homology Class Report.
The Vertebrate Homology Report contains:
MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.
MGI includes homology for the following selected vertebrate species from the Alliance of Genome Resources:
These are a subset of the total species represented in the Alliance. There may be stringent set orthologs in other Alliance species.
For each homolog in the set, the record shows some or all information in the following table, depending on the information available.
|Species | Symbol | Gene Links | Genetic Location | Genome Coordinates | Associated Human Diseases | Sequences|
|Species||Species name of each homolog in a class.|
|Symbol||Symbol for an homologous marker.|
|Gene Links||Database accession IDs assigned to the marker, linked to the database where the marker record is stored.|
|Genetic Location||The chromosome the marker is assigned to and the cM position or cytogenetic band. Location information varies depending on information available.|
|Genome Coordinates||Genome coordinate range in base pairs, strand and the genome build number.|
|Associated Human Diseases||Human Disease Ontology (DO) terms, linked to MGI Disease Ontology Browser. Diseases that are only annotated to complex genotypes—those involving more than one genome feature—are not listed in this summary. See also the Disease Ontology Browser.|
|Sequences||Representative transcript and protein sequence ID, linked to the provider's web site. Check boxes permit downloading selected sequences in FASTA format or forward to BLAST at NCBI.|
Yes. Just above the table is a link to a Multiple Genome Viewer that allows you to browse and compare regions around the feature. By default the Viewer launches with genomes shown for mouse, human, and rat, but you can add other species and mouse strains.
To forward sequences to NCBI BLAST: