Sequence Detail

ID/Version

Q9WVG6 Q3TYB9 Q8K1Y5 Q91W24 Q99KX8 (UniProt | EBI)

Last sequence update: 2004-09-13
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Histone-arginine methyltransferase CARM1; EC=2.1.1.319 {ECO:0000269|PubMed:11341840, ECO:0000269|PubMed:17882261, ECO:0000269|PubMed:19843527, ECO:0000269|PubMed:19897492, ECO:0000269|PubMed:21138967};AltName: Full=Coactivator-associ

Provider

SWISS-PROT

Sequence

Polypeptide 608 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Carm1	coactivator-associated arginine methyltransferase 1	60	118	3	79

Sequence references in MGI

J:64957 Chen D, et al., Regulation of transcription by a protein methyltransferase. Science. 1999 Jun 25;284(5423):2174-7
J:83623 Yadav N, et al., Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6464-8
J:88187 Lee YH, et al., Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol. 2004 Mar;24(5):2103-17
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105108 Covic M, et al., Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 2005 Jan 12;24(1):85-96
J:159958 Kim D, et al., Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 8;285(2):1147-52
J:168187 Feng Q, et al., Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009 Dec 25;284(52):36167-74
J:168191 Yadav N, et al., CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008 Feb;9(2):193-8
J:168193 Yue WW, et al., Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO J. 2007 Oct 17;26(20):4402-12
J:172897 Schurter BT, et al., Methylation of histone H3 by coactivator-associated arginine methyltransferase 1. Biochemistry. 2001 May 15;40(19):5747-56
J:173802 Kuhn P, et al., Automethylation of CARM1 allows coupling of transcription and mRNA splicing. Nucleic Acids Res. 2011 Apr;39(7):2717-26
J:272605 Liu Y, et al., A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress. Genes Dev. 2018 Nov 1;32(21-22):1380-1397
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89