Sequence Detail

ID/Version

Q9QZ59 Q19AV2 Q6Y953 Q6Y951 Q2TDQ9 Q9QZA4 Q9QZ37 (UniProt | EBI)

Last sequence update: 2012-04-18
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Doublesex- and mab-3-related transcription factor 1;

Provider

SWISS-PROT

Sequence

Polypeptide 374 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dmrt1	doublesex and mab-3 related transcription factor 1	46	127	3	29

Sequence references in MGI

J:58410 Raymond CS, et al., Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Dev Biol. 1999 Nov 15;215(2):208-20
J:58958 Smith CA, et al., Conservation of a sex-determining gene. Nature. 1999 Dec 9;402(6762):601-2
J:60422 De Grandi A, et al., The expression pattern of a mouse doublesex-related gene is consistent with a role in gonadal differentiation. Mech Dev. 2000 Feb;90(2):323-6
J:65541 Raymond CS, et al., Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev. 2000 Oct 15;14(20):2587-95
J:116624 Lu H, et al., Multiple alternative splicing of mouse Dmrt1 during gonadal differentiation. Biochem Biophys Res Commun. 2007 Jan 19;352(3):630-4
J:122954 Kim S, et al., Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation. Dev Biol. 2007 Jul 15;307(2):314-27
J:156489 Krentz AD, et al., The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22323-8
J:162401 Murphy MW, et al., Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13360-5
J:166057 Matson CK, et al., The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. Dev Cell. 2010 Oct 19;19(4):612-24
J:174935 Matson CK, et al., DMRT1 prevents female reprogramming in the postnatal mammalian testis. Nature. 2011 Aug 4;476(7358):101-4
J:175257 Krentz AD, et al., DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary. Dev Biol. 2011 Aug 1;356(1):63-70
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89