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Sequence Detail
Q9ET39 C6ESQ1 Q9ET40 (UniProt | EBI) Last sequence update: 2001-03-01
Last annotation update: 2018-03-28
from provider
RecName: Full=SLAM family member 6;AltName: Full=Lymphocyte antigen 108;AltName: CD_antigen=CD352;Flags: Precursor;
Polypeptide 351 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Slamf6 SLAM family member 6 13 0 6 10
Sequence references in MGI J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
J:127620 Griewank K, et al., Homotypic interactions mediated by slamf1 and slamf6 receptors control NKT cell lineage development. Immunity. 2007 Nov;27(5):751-62
J:151768 Dong Z, et al., Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells. Nat Immunol. 2009 Sep;10(9):973-80
J:157915 Cannons JL, et al., Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity. 2010 Feb 26;32(2):253-65
J:177322 Keszei M, et al., A novel isoform of the Ly108 gene ameliorates murine lupus. J Exp Med. 2011 Apr 11;208(4):811-22
J:187429 Kageyama R, et al., The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity. 2012 Jun 29;36(6):986-1002
J:244548 Wong EB, et al., B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. J Immunol. 2015 May 01;194(9):4130-43
J:244675 Wang N, et al., Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Front Immunol. 2015;6(None):158

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last database update
MGI 6.12
The Jackson Laboratory