Sequence Detail

ID/Version

Q91VS8 Q3TAP2 E9QJS4 Q69ZZ0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=FERM, ARHGEF and pleckstrin domain-containing protein 2;AltName: Full=FERM domain including RhoGEF; Short=FIR;AltName: Full=FERM, RhoGEF and pleckstrin domain-containing protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1065 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Farp2	FERM, RhoGEF and pleckstrin domain protein 2	15	98	3	7

Sequence references in MGI

J:79193 Kubo T, et al., A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J Neurosci. 2002 Oct 1;22(19):8504-13
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103842 Toyofuku T, et al., FARP2 triggers signals for Sema3A-mediated axonal repulsion. Nat Neurosci. 2005 Dec;8(12):1712-9
J:166376 Takegahara N, et al., Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangements. FASEB J. 2010 Dec;24(12):4782-92
J:196400 He X, et al., Structural basis for autoinhibition of the guanine nucleotide exchange factor FARP2. Structure. 2013 Mar 5;21(3):355-64
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89