Sequence Detail

ID/Version

Q8BGE6 Q6ZQ22 Q8R098 (UniProt | EBI)

Last sequence update: 2005-03-15
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Cysteine protease ATG4B {ECO:0000305}; EC=3.4.22.- {ECO:0000269|PubMed:14530254, ECO:0000269|PubMed:29458288};AltName: Full=AUT-like 1 cysteine endopeptidase;AltName: Full=Autophagy-related cysteine endopeptidase 1 {ECO:0000303|PubMe

Provider

SWISS-PROT

Sequence

Polypeptide 393 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atg4b	autophagy related 4B, cysteine peptidase	46	101	3	21

Sequence references in MGI

J:81439 Marino G, et al., Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy. J Biol Chem. 2003 Feb 7;278(6):3671-8
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:87279 Hemelaar J, et al., A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. J Biol Chem. 2003 Dec 19;278(51):51841-50
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:163712 Marino G, et al., Autophagy is essential for mouse sense of balance. J Clin Invest. 2010 Jul 1;120(7):2331-44
J:172364 Kim BH, et al., A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science. 2011 May 6;332(6030):717-21
J:186046 Read R, et al., Histopathological and neurological features of Atg4b knockout mice. Vet Pathol. 2011 Mar;48(2):486-94
J:193725 Kuang E, et al., Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet. 2012;8(10):e1003007
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314374 Kauffman KJ, et al., Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases. Autophagy. 2018;14(6):992-1010