Sequence Detail

ID/Version

Q8BG87 Q4VAD3 Q8CI60 Q8C8N8 K9JH93 L0HN04 (UniProt | EBI)

Last sequence update: 2019-11-13
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Methylcytosine dioxygenase TET3; EC=1.14.11.80 {ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:23690950, ECO:0000269|PubMed:26774490};

Provider

SWISS-PROT

Sequence

Polypeptide 1803 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tet3	tet methylcytosine dioxygenase 3	27	108	3	17

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:163464 Ito S, et al., Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010 Jul 18;466(7310):1129-1133
J:169869 Iqbal K, et al., Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3642-7
J:175793 Ito S, et al., Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science. 2011 Sep 2;333(6047):1300-3
J:176196 Gu TP, et al., The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011 Sep 29;477(7366):606-10
J:186710 Nakamura T, et al., PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature. 2012 Jun 21;486(7403):415-9
J:192647 Wossidlo M, et al., 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun. 2011;2:241
J:194101 Yamaguchi S, et al., Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
J:203146 Liu N, et al., Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules. PLoS One. 2013;8(5):e62755
J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
J:219980 Nakagawa T, et al., CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Mol Cell. 2015 Jan 22;57(2):247-60
J:254851 Hatanaka Y, et al., Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Cell Rep. 2017 Sep 19;20(12):2756-2765
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87