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Sequence Detail
ID/Version
Q80W65 Q8BXW9 Q3UEH7 Q8CFT6 B1AZI4 (UniProt | EBI) Last sequence update: 2003-11-07
Last annotation update: 2019-07-31
Sequence
description
from provider
RecName: Full=Proprotein convertase subtilisin/kexin type 9; EC=3.4.21.-;AltName: Full=Neural apoptosis-regulated convertase 1; Short=NARC-1;AltName: Full=Proprotein convertase 9; Short=PC9;AltName: Full=Subtilisin/kexin-like prote
Provider SWISS-PROT
Sequence
Polypeptide 694 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Pcsk9 proprotein convertase subtilisin/kexin type 9 77 6 7 16
Sequence references in MGI J:81825 Seidah NG, et al., The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33
J:93102 Maxwell KN, et al., Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice. J Lipid Res. 2003 Nov;44(11):2109-19
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:186176 Sun H, et al., Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor. Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1585-95
J:186215 Kysenius K, et al., PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling. Cell Mol Life Sci. 2012 Jun;69(11):1903-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory