Sequence Detail

ID/Version

Q6ZWR6 Q8K3T7 Q9ERT7 Q9ERT8 (UniProt | EBI)

Last sequence update: 2010-03-23
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=Nesprin-1 {ECO:0000305};AltName: Full=Enaptin;AltName: Full=KASH domain-containing protein 1; Short=KASH1;AltName: Full=Myocyte nuclear envelope protein 1; Short=Myne-1;AltName: Full=Nuclear envelope spectrin repeat protein 1

Provider

SWISS-PROT

Sequence

Polypeptide 8799 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Syne1	spectrin repeat containing, nuclear envelope 1	66	101	4	15

Sequence references in MGI

J:65130 Apel ED, et al., Syne-1, A dystrophin- and klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction. J Biol Chem. 2000 Oct 13;275(41):31986-95
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150047 Lei K, et al., SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10207-12
J:153287 Dawe HR, et al., Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. J Cell Sci. 2009 Aug 1;122(Pt 15):2716-26
J:155113 Zhang X, et al., SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009 Oct 29;64(2):173-87
J:187540 Taranum S, et al., Cytoskeletal interactions at the nuclear envelope mediated by nesprins. Int J Cell Biol. 2012;2012:736524
J:234041 Pasch E, et al., The LINC complex component Sun4 plays a crucial role in sperm head formation and fertility. Biol Open. 2015;4(12):1792-802
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89