Sequence Detail

ID/Version

Q6ZPF3 Q3TSM6 Q9JLY2 Q9WVS3 Q6AXF2 Q3TZ33 Q6NXJ2 (UniProt | EBI)

Last sequence update: 2008-02-05
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Rho guanine nucleotide exchange factor TIAM2 {ECO:0000305|PubMed:10364228};AltName: Full=SIF and TIAM1-like exchange factor;AltName: Full=T-lymphoma invasion and metastasis-inducing protein 2 {ECO:0000305}; Short=TIAM-2;

Provider

SWISS-PROT

Sequence

Polypeptide 1715 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tiam2	T cell lymphoma invasion and metastasis 2	17	108	3	8

Sequence references in MGI

J:55621 Hoshino M, et al., Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. J Biol Chem. 1999 Jun 18;274(25):17837-44
J:73960 Matsuo N, et al., Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth. J Biol Chem. 2002 Jan 25;277(4):2860-8
J:76232 Yoshizawa M, et al., Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain. Mech Dev. 2002 Apr;113(1):65-8
J:85971 Matsuo N, et al., Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology. Mol Cell Neurosci. 2003 Sep;24(1):69-81
J:86686 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Aug 31;10(4):167-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:156410 Terawaki S, et al., The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. EMBO J. 2010 Jan 6;29(1):236-50
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89