Sequence Detail

ID/Version

Q64364 Q4U255 Q9R051 Q9QXC7 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Tumor suppressor ARF {ECO:0000305};AltName: Full=Alternative reading frame; Short=ARF;AltName: Full=Cyclin-dependent kinase inhibitor 2A;AltName: Full=p19ARF;

Provider

SWISS-PROT

Sequence

Polypeptide 169 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cdkn2a	cyclin dependent kinase inhibitor 2A	130	150	3	57

Sequence references in MGI

J:38065 Herzog CR, et al., Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene. Mamm Genome. 1997 Jan;8(1):65-6
J:41563 Quelle DE, et al., Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell. 1995 Dec 15;83(6):993-1000
J:44427 Kamijo T, et al., Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997 Nov 28;91(5):649-59
J:54019 Inoue K, et al., Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3993-8
J:61786 Melendez B, et al., Characterization of the murine p19(ARF) promoter CpG island and its methylation pattern in primary lymphomas. Carcinogenesis. 2000 Apr;21(4):817-21
J:63444 Inoue K, et al., Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Genes Dev. 2000 Jul 15;14(14):1797-809
J:79357 Hasan MK, et al., CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem. 2002 Oct 4;277(40):37765-70
J:91428 Yi Y, et al., p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell. 2004 May;15(5):2302-11
J:93211 Qi Y, et al., p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature. 2004 Oct 7;431(7009):712-7
J:94162 Suzuki H, et al., The ARF tumor suppressor inhibits BCL6-mediated transcriptional repression. Biochem Biophys Res Commun. 2004 Dec 31;326(1):242-8
J:111292 Reef S, et al., A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol Cell. 2006 May 19;22(4):463-75
J:126002 Mallakin A, et al., Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Cancer Cell. 2007 Oct;12(4):381-94
J:127208 Tompkins VS, et al., A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability. J Biol Chem. 2007 Jan 12;282(2):1322-33
J:162926 Lessard F, et al., The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I. Mol Cell. 2010 May 28;38(4):539-50
J:189986 Reef S, et al., The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein. Oncogene. 2007 Oct 11;26(46):6677-83