Sequence Detail

ID/Version

Q62137 A2RRI3 Q8BTY6 Q8BYU2 Q61747 Q61746 Q0D2M8 (UniProt | EBI)

Last sequence update: 2007-08-21
Last annotation update: 2023-11-08

Sequence description from provider

RecName: Full=Tyrosine-protein kinase JAK3 {ECO:0000305}; EC=2.7.10.2;AltName: Full=Janus kinase 3; Short=JAK-3;

Provider

SWISS-PROT

Sequence

Polypeptide 1100 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Jak3	Janus kinase 3	62	107	3	37

Sequence references in MGI

J:19201 Witthuhn BA, et al., Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature. 1994 Jul 14;370(6485):153-7
J:19408 Rane SG, et al., JAK3: a novel JAK kinase associated with terminal differentiation of hematopoietic cells. Oncogene. 1994 Aug;9(8):2415-23
J:29722 Thomis DC, et al., Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3;270(5237):794-7
J:29723 Nosaka T, et al., Defective lymphoid development in mice lacking Jak3. Science. 1995 Nov 3;270(5237):800-2
J:32601 Gurniak CB, et al., Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood. 1996 Apr 15;87(8):3151-60
J:47917 Baird AM, et al., T cell development and activation in Jak3-deficient mice. J Leukoc Biol. 1998 Jun;63(6):669-77
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:128694 Thomis DC, et al., Peripheral expression of Jak3 is required to maintain T lymphocyte function. J Exp Med. 1997 Jan 20;185(2):197-206
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89