Sequence Detail

ID/Version

Q61584 Q9WUA9 Q9WUA8 Q9R1E4 Q8VCU4 Q9WUA7 Q9R1E2 Q9R1E3 Q9R1E5 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=RNA-binding protein FXR1 {ECO:0000305}; Short=FXR1P {ECO:0000303|PubMed:22022532}; Short=mFxr1p {ECO:0000303|PubMed:11438699};

Provider

SWISS-PROT

Sequence

Polypeptide 677 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fxr1	FMR1 autosomal homolog 1	90	121	3	332

Sequence references in MGI

J:30134 Coy JF, et al., Highly conserved 3' UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. Hum Mol Genet. 1995 Dec;4(12):2209-18
J:56616 Kirkpatrick LL, et al., Alternative splicing in the murine and human FXR1 genes. Genomics. 1999 Jul 15;59(2):193-202
J:88664 Schenck A, et al., A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8844-9
J:91191 Mientjes EJ, et al., Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo. Hum Mol Genet. 2004 Jul 1;13(13):1291-302
J:96927 Garnon J, et al., Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level. J Biol Chem. 2005 Feb 18;280(7):5750-63
J:103915 Huot ME, et al., The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis. Mol Biol Cell. 2005 Sep;16(9):4350-61
J:179583 Cook D, et al., Fragile X related protein 1 clusters with ribosomes and messenger RNAs at a subset of dendritic spines in the mouse hippocampus. PLoS One. 2011;6(10):e26120
J:218753 Cook D, et al., FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation. Cell Rep. 2014 Nov 20;9(4):1402-16
J:242048 Patzlaff NE, et al., Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. Hum Mol Genet. 2017 Apr 01;26(7):1340-1352
J:255973 Qie S, et al., Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 Nov 16;8(1):1534
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:263455 Wang GX, et al., Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. Elife. 2016 Oct 22;5:e20560
J:276784 Estan MC, et al., Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy. Nat Commun. 2019 Feb 15;10(1):797
J:291328 Smith JA, et al., FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. J Cell Biol. 2020 Apr 6;219(4)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:305336 Khlghatyan J, et al., Fxr1 regulates sleep and synaptic homeostasis. EMBO J. 2020 Nov 2;39(21):e103864
J:332641 Kang JY, et al., LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs. Science. 2022 Aug 12;377(6607):eabj6647
J:332980 Del'Guidice T, et al., FXR1P is a GSK3beta substrate regulating mood and emotion processing. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4610-9