Sequence Detail

ID/Version

Q60856 A8YPE5 Q78ZX0 A8YPE7 A8YPE9 Q8VI98 A8YPE8 Q8JZN0 Q8JZN4 E9QKP6 (UniProt | EBI)

Last sequence update: 2012-09-05
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Inactive 2'-5'-oligoadenylate synthase 1B; Short=(2-5')oligo(A) synthase 1B; Short=2-5A synthase 1B;AltName: Full=2'-5'-oligoadenylate synthase-like protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 376 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Pseudogene	Oas1b	2'-5' oligoadenylate synthetase 1B	46	97	2	7

Sequence references in MGI

J:11163 Rutherford MN, et al., The murine 2-5A synthetase locus: three distinct transcripts from two linked genes. Nucleic Acids Res. 1991 Apr 25;19(8):1917-24
J:77001 Perelygin AA, et al., Positional cloning of the murine flavivirus resistance gene. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9322-7
J:78974 Mashimo T, et al., A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11311-6
J:175365 Scherbik SV, et al., Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype. Virology. 2007 Nov 25;368(2):232-7
J:175745 Kakuta S, et al., Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. J Interferon Cytokine Res. 2002 Sep;22(9):981-93
J:185034 Perelygin AA, et al., The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla. J Mol Evol. 2006 Oct;63(4):562-76
J:186172 Courtney SC, et al., Identification of novel host cell binding partners of oas1b, the protein conferring resistance to flavivirus-induced disease in mice. J Virol. 2012 Aug;86(15):7953-63
J:188903 Kajaste-Rudnitski A, et al., The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells. J Biol Chem. 2006 Feb 24;281(8):4624-37