Sequence Detail

ID/Version

P70406 O88285 (UniProt | EBI)

Last sequence update: 1997-02-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Dicarboxylate carrier SLC25A8 {ECO:0000250|UniProtKB:P55851};AltName: Full=Mitochondrial uncoupling protein 2; Short=UCP 2;AltName: Full=Solute carrier family 25 member 8;AltName: Full=UCPH;

Provider

SWISS-PROT

Sequence

Polypeptide 309 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)	65	116	3	49

Sequence references in MGI

J:40062 Gimeno RE, et al., Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes. 1997 May;46(5):900-6
J:49103 Yamada M, et al., Genomic organization and promoter function of the mouse uncoupling protein 2 (UCP2) gene. FEBS Lett. 1998 Jul 31;432(1-2):65-9
J:66262 Arsenijevic D, et al., Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000 Dec;26(4):435-9
J:73708 Krauss S, et al., A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):118-22
J:120450 Couplan E, et al., No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem. 2002 Jul 19;277(29):26268-75
J:215570 Berardi MJ, et al., Fatty acid flippase activity of UCP2 is essential for its proton transport in mitochondria. Cell Metab. 2014 Sep 2;20(3):541-52
J:230799 Toda C, et al., UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness. Cell. 2016 Feb 25;164(5):872-83
J:319416 Faas M, et al., IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021 Nov 9;54(11):2531-2546.e5