About   Help   FAQ
Sequence Detail
P70232 Q8VBY7 Q8BS24 Q8C823 Q8C6W0 A2RRK1 (UniProt | EBI) Last sequence update: 2012-10-03
Last annotation update: 2018-11-07
from provider
RecName: Full=Neural cell adhesion molecule L1-like protein;AltName: Full=Cell adhesion molecule with homology to L1CAM;AltName: Full=Chl1-like protein;AltName: Full=Close homolog of L1;Contains: RecName: Full=Processed neural cell adhesion molecule L1-l
Polypeptide 1209 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Chl1 cell adhesion molecule L1-like 22 8 8 4
Sequence references in MGI J:36169 Holm J, et al., Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules. Eur J Neurosci. 1996 Aug;8(8):1613-29
J:55994 Hillenbrand R, et al., The close homologue of the neural adhesion molecule L1 (CHL1): patterns of expression and promotion of neurite outgrowth by heterophilic interactions. Eur J Neurosci. 1999 Mar;11(3):813-26
J:79902 Montag-Sallaz M, et al., Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol Cell Biol. 2002 Nov;22(22):7967-81
J:84464 Frints SG, et al., CALL interrupted in a patient with non-specific mental retardation: gene dosage-dependent alteration of murine brain development and behavior. Hum Mol Genet. 2003 Jul 1;12(13):1463-74
J:89492 Naus S, et al., Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death. J Biol Chem. 2004 Apr 16;279(16):16083-90
J:96214 Pratte M, et al., Mice deficient for the close homologue of the neural adhesion cell L1 (CHL1) display alterations in emotional reactivity and motor coordination. Behav Brain Res. 2003 Dec 17;147(1-2):31-9
J:96525 Demyanenko GP, et al., Close homolog of L1 modulates area-specific neuronal positioning and dendrite orientation in the cerebral cortex. Neuron. 2004 Oct 28;44(3):423-37
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:108067 Nikonenko AG, et al., Enhanced perisomatic inhibition and impaired long-term potentiation in the CA1 region of juvenile CHL1-deficient mice. Eur J Neurosci. 2006 Apr;23(7):1839-52
J:166027 Buhusi M, et al., Close homolog of L1 is an enhancer of integrin-mediated cell migration. J Biol Chem. 2003 Jul 4;278(27):25024-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory