Sequence Detail

ID/Version

P68404 A0JNZ5 P04410 P04411 F2Z441 (UniProt | EBI)

Last sequence update: 2011-09-21
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Protein kinase C beta type; Short=PKC-B; Short=PKC-beta; EC=2.7.11.13;

Provider

SWISS-PROT

Sequence

Polypeptide 671 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Prkcb	protein kinase C, beta	84	119	4	16

Sequence references in MGI

J:10740 Tang YM, et al., Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence. Nucleic Acids Res. 1990 Sep 11;18(17):5310
J:34818 Leitges M, et al., Immunodeficiency in protein kinase cbeta-deficient mice. Science. 1996 Aug 9;273(5276):788-91
J:73979 Suzuma K, et al., Characterization of protein kinase C beta isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):721-6
J:84787 Kawakami Y, et al., A Ras activation pathway dependent on Syk phosphorylation of protein kinase C. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9470-5
J:106858 Naruse K, et al., Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar;55(3):691-8
J:108802 Standaert ML, et al., Effects of knockout of the protein kinase C beta gene on glucose transport and glucose homeostasis. Endocrinology. 1999 Oct;140(10):4470-7
J:109151 Su TT, et al., PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol. 2002 Aug;3(8):780-6
J:113308 Sommer K, et al., Phosphorylation of the CARMA1 linker controls NF-kappaB activation. Immunity. 2005 Dec;23(6):561-74
J:118843 Shinohara H, et al., PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med. 2005 Nov 21;202(10):1423-31
J:130299 Bansode RR, et al., Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage. J Biol Chem. 2008 Jan 4;283(1):231-6
J:187362 Munton RP, et al., Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Mol Cell Proteomics. 2007 Feb;6(2):283-93
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89