Sequence Detail

ID/Version

P52912 (UniProt | EBI)

Last sequence update: 1996-10-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Cytotoxic granule associated RNA binding protein TIA1 {ECO:0000312|MGI:MGI:107914};AltName: Full=Nucleolysin TIA-1 {ECO:0000305};AltName: Full=RNA-binding protein TIA-1;AltName: Full=T-cell-restricted intracellular antigen-1; Short=T

Provider

SWISS-PROT

Sequence

Polypeptide 386 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tia1	cytotoxic granule-associated RNA binding protein 1	32	104	4	38

Sequence references in MGI

J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
J:36355 Lowin B, et al., Expression of the CTL-associated protein TIA-1 during murine embryogenesis. J Immunol. 1996 Aug 15;157(4):1448-54
J:88770 Piecyk M, et al., TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 2000 Aug 1;19(15):4154-63
J:112748 Zhang T, et al., Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins. J Cell Sci. 2005 Dec 1;118(Pt 23):5453-63
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314553 Rayman JB, et al., TIA-1 Self-Multimerization, Phase Separation, and Recruitment into Stress Granules Are Dynamically Regulated by Zn(2). Cell Rep. 2018 Jan 2;22(1):59-71
J:314554 Le Guiner C, et al., TIA-1 and TIAR activate splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on their own pre-mRNAs. J Biol Chem. 2001 Nov 2;276(44):40638-46
J:314555 Lopez de Silanes I, et al., Identification and functional outcome of mRNAs associated with RNA-binding protein TIA-1. Mol Cell Biol. 2005 Nov;25(21):9520-31
J:314640 Del Gatto-Konczak F, et al., The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site. Mol Cell Biol. 2000 Sep;20(17):6287-99