Sequence Detail

ID/Version

P35569 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Insulin receptor substrate 1; Short=IRS-1;

Provider

SWISS-PROT

Sequence

Polypeptide 1233 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Irs1	insulin receptor substrate 1	105	103	3	21

Sequence references in MGI

J:4645 Keller SR, et al., The insulin-elicited 160 kDa phosphotyrosine protein in mouse adipocytes is an insulin receptor substrate 1: identification by cloning. Biochim Biophys Acta. 1993 Mar 20;1172(3):323-6
J:17970 Araki E, et al., Cloning of the mouse insulin receptor substrate-1 (IRS-1) gene and complete sequence of mouse IRS-1. Biochim Biophys Acta. 1994 Apr 28;1221(3):353-6
J:21374 Araki E, et al., Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene [see comments]. Nature. 1994 Nov 10;372(6502):186-90
J:61479 Ogata N, et al., Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest. 2000 Apr;105(7):935-43
J:66245 Iwanishi M, et al., The protein-tyrosine kinase fer associates with signaling complexes containing insulin receptor substrate-1 and phosphatidylinositol 3-kinase. J Biol Chem. 2000 Dec 15;275(50):38995-9000
J:66427 Farhang-Fallah J, et al., Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein. J Biol Chem. 2000 Dec 22;275(51):40492-7
J:129786 Furukawa N, et al., Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug;2(2):119-29
J:192911 Carvalho-Filho MA, et al., Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology. 2012 Nov;153(11):5261-74
J:193983 Kim SJ, et al., mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell. 2012 Dec 28;48(6):875-87
J:207232 Seldin MM, et al., Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013 Dec 13;288(50):36073-82
J:265598 Ando Y, et al., Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Ialpha causes insulin resistance in 3T3-L1 adipocytes. J Biol Chem. 2015 Feb 27;290(9):5881-92
J:265618 Liu T, et al., A novel IRS-1-associated protein, DGKzeta regulates GLUT4 translocation in 3T3-L1 adipocytes. Sci Rep. 2016 Oct 14;6:35438
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89