Sequence Detail

ID/Version

P35363 (UniProt | EBI)

Last sequence update: 1994-06-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=5-hydroxytryptamine receptor 2A; Short=5-HT-2; Short=5-HT-2A;AltName: Full=Serotonin receptor 2A;

Provider

SWISS-PROT

Sequence

Polypeptide 471 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	78	110	4	16

Sequence references in MGI

J:3194 Yang W, et al., Gene structure and expression of the mouse 5-HT2 receptor. J Neurosci Res. 1992 Oct;33(2):196-204
J:108058 Fiorica-Howells E, et al., 5-HT(2A) receptors: location and functional analysis in intestines of wild-type and 5-HT(2A) knockout mice. Am J Physiol Gastrointest Liver Physiol. 2002 May;282(5):G877-93
J:110958 Weisstaub NV, et al., Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science. 2006 Jul 28;313(5786):536-40
J:122935 Gonzalez-Maeso J, et al., Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. Neuron. 2007 Feb 1;53(3):439-52
J:136808 Gonzalez-Maeso J, et al., Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6;452(7183):93-7
J:308957 Moreno JL, et al., Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012 Dec 28;287(53):44301-19
J:333121 Becamel C, et al., The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins. J Biol Chem. 2004 May 7;279(19):20257-66